Planta Med 2016; 82(11/12): 942-951
DOI: 10.1055/s-0042-107081
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs[*]

José-Luis Ríos
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
,
María Onteniente
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
,
Dolores Picazo
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
,
María-Carmen Montesinos
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
› Author Affiliations
Further Information

Publication History

received 25 February 2016
revised 05 April 2016

accepted 10 April 2016

Publication Date:
25 May 2016 (eFirst)

Abstract

Parkinsonʼs disease is a progressive neurodegenerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigrostriatal system with a consequent dopamine decrease. The reduction of dopamine levels produces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. Treatments for Parkinsonʼs disease aim for improving these motor symptoms by increasing the dopaminergic signal in the striatum with levodopa in combination with enzyme inhibitors or anticholinergic drugs. Nevertheless, natural products can act as neuroprotective agents by reducing the progression of the disease and the inflammatory process.

In the present review, we have compiled data on the principal medicinal plants and natural products as potential antiparkinsonian agents. They act by different mechanisms, such as the inhibition of α-synuclein condensation, reduction of oxidative stress and neuro-inflammation, increase of dopaminergic neurons survival, or the blockade of the A2 A receptor.

* Dedicated to Professor Dr. Dr. h. c. mult. Kurt Hostettmann in recognition of his outstanding contribution to natural product research.