Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Karin Fürer; Ana Paula Simões-Wüst; Ursula von Mandach; Matthias Hamburger; Olivier Potterat

doi:10.1055/s-0042-106727

Planta Medica, Table of Contents

Planta Med 2016; 82(11/12): 930-941
DOI: 10.1055/s-0042-106727

Reviews

Georg Thieme Verlag KG Stuttgart · New York

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy^[*]

Karin Fürer

¹Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

²Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

,

Ana Paula Simões-Wüst

²Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

,

Ursula von Mandach

²Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

,

Matthias Hamburger

¹Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

,

Olivier Potterat

¹Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

› Author Affiliations

Abstract

Bryophyllum pinnatum (syn. Kalanchoe pinnata) is a succulent perennial plant native to Madagascar that was introduced in anthroposophic medicine in the early 20th century. In recent years, we conducted a large collaborative project to provide reliable data on the chemical composition, pharmacological properties, and clinical efficacy of Bryophyllum. Here, we comprehensively review the phytochemistry, as well as the pharmacological and clinical data. As to the pharmacology, special emphasis is given to properties related to the use in anthroposophic medicine as a treatment for “hyperactivity diseases”, such as preterm labor, restlessness, and sleep disorders. Studies suggesting that B. pinnatum may become a new treatment option for overactive bladder syndrome are also reviewed. Tolerability is addressed, and toxicological data are discussed in conjunction with the presence of potentially toxic bufadienolides in Bryophyllum species. The few data available on two related species with medicinal uses, Bryophyllum daigremontianum and Bryophyllum delagoense, have also been included. Taken together, current data support the use of B. pinnatum for the mentioned indications, but further studies are needed to fully understand the modes of action, and to identify the pharmacologically active constituents.

Key words

Bryophyllum pinnatum - Bryophyllum daigremontianum - Bryophyllum delagoense - Crassulaceae - constituents - anthroposophic medicine - pharmacological activities - clinical studies

Full Text

References

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Supplementary Material

Supporting Information

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy[*]

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy^[*]