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Aktuelle Rheumatologie 2017; 42(05): 423-431
DOI: 10.1055/s-0042-105952
Übersichtsarbeit
Georg Thieme Verlag KG Stuttgart · New York

Fluoreszenzoptische Bildgebung

Fluorescence Optical Imaging
S. Werner
1   Arbeitsgruppe Bildgebung, Medizinische Klinik mit Schwerpunkt Rheumatologie u. Klinische Immunologie (einschl. Arbeitsbereich Physikalische Medizin CBF/CCM), Charite Universitatsmedizin Berlin, Berlin
,
H.-E. Langer
2   RHIO (Rheumatologie, Immunologie, Osteologie) Düsseldorf, Düsseldorf
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
11. Juli 2016 (online)

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Zusammenfassung

ICG-gestützte fluoreszenzoptische Bildgebung (fluoreszenzoptisches Imaging, FOI) ist eine neuere Technologie zur Entzündungsdiagnostik. Mit der Darstellung von (Neo)Angiogenese, Hypervaskularisation, Hyperämie und veränderter Kapillarpermeabilität stützt sie sich auf frühe pathomorphologische Veränderungen in der Pathogenese einer Arthritis. Umfangreiche Validierungsstudien gegenüber Arthrosonografie einschließlich Power-Doppler-Sonografie und MRT zeigen eine hohe Sensitivität und Spezifität. Die Methode erweitert das diagnostische Armamentarium insbesondere bei der Früharthritisdiagnostik, der Differenzialdiagnostik, der Verlaufsbeurteilung und beim Therapiemonitoring entzündlich-rheumatischer Erkrankungen und in der Kinderrheumatologie und eröffnet zum Teil neue diagnostische Fenster. Als lichtoptisches, fluorophor-gestütztes, mikroangiografisches Verfahren verwendet FOI andere physikalische Grundlagen als die herkömmliche Bildgebung und tritt damit nicht als konkurrierende Methode auf, sondern ergänzt die konventionellen Techniken in einem bislang nicht abgedeckten, speziellen diagnostischen Bereich.

Abstract

ICG-enhanced fluorescence optical imaging (FOI) is a novel technology for the detection of inflammatory changes. By demonstrating (neo)angiogenesis, hypervascularisation, hyperaemia and altered capillary permeability, this method focuses on early pathomorphological events in the pathogenesis of arthritis. Comprehensive validation studies have shown high sensitivity and specificity compared to articular ultrasound, Power Doppler arthrosonography and MRI. This method extends the diagnostic armamentarium, especially in the diagnosis of early arthritis, differential diagnosis, evaluation of treatment response, the monitoring of inflammatory rheumatic diseases and in the field of paediatric rheumatology, and may open new diagnostic windows. Compared to the traditional imaging techniques, FOI is based on different physical principles such as light optics, fluorophores, and microangiography. Used as a complementary but not a competitive method it will allow us to address a hitherto uncovered diagnostic field.

Schlüsselwörter

Fluoreszenzoptische Bildgebung - ICG - Indocyaningrün - Xiralite - Rheumascan

Key words

fluorescence optical imaging - ICG - indocyanine green - xiralite - rheumascan
 

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