Planta Med 2016; 82(08): 717-722
DOI: 10.1055/s-0042-104283
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial and Cytotoxic Activity of Raw Plant Extracts as Reported by Knowledgeable Indigenous People of the Amazon Region (Vaupés Medio in Colombia)

Adriana Pabón
1   Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
,
Otoniel Ramirez
1   Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
,
Alexandra Ríos
1   Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
,
Ena López
1   Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
,
Briegel de las Salas
1   Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
,
Felipe Cardona
2   Herbario Universidad de Antioquia, Medellín, Colombia
,
Silvia Blair
1   Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
› Author Affiliations
Further Information

Publication History

received 28 May 2015
revised 14 February 2016

accepted 27 February 2016

Publication Date:
28 April 2016 (online)

Abstract

The in vitro antiplasmodial activity of 122 raw extracts prepared in ethanol and water from 35 medicinal plants reported by the Cubeo indigenous village of the Amazon region (Vaupés Medio in Colombia) was evaluated for efficacy against 3D7 (sensitive to chloroquine) and FCR-3 (resistant to chloroquine) Plasmodium falciparum strains. Five percent of these extracts presented a significant antiplasmodial activity (< 5 µg/mL) and 83 % of them were not cytotoxic. These findings highlight the importance of investigating traditional medicinal plants implemented by these ancestral communities of the Amazon region as well as their potential to become a source of new drugs against malaria.

 
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