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Planta Med 2016; 82(06): 505-515
DOI: 10.1055/s-0042-103495
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Chemical Adulterants in Herbal Medicinal Products: A Review

Jacob Calahan
1   Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA
,
Dylan Howard
1   Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA
,
Ahmad J. Almalki
1   Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA
2   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom Saudi Arabia
,
Mahabir P. Gupta
3   Centro de Investigaciones Farmacognósticas de la Flora Panameña, Facultad de Farmacia, Universidad de Panamá, Panamá, República de Panamá
,
Angela I. Calderón
1   Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA
› Author Affiliations
Further Information

Publication History

received 31 July 2015
revised 31 January 2016

accepted 10 February 2016

Publication Date:
07 April 2016 (online)

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Abstract

Many herbal medicinal products have been found to contain synthetic prescription drugs as chemical adulterants. This has become evident by the number of toxicity cases and adverse reactions reported in which casualties were reported via analytical techniques that detected the presence of chemical adulterants in them, which could be responsible for their toxicity. The adulteration of herbal medicinal products with synthetic drugs continues to be a serious problem for regulatory agencies. This review provides up to date information on cases of toxicity, major chemical adulterants in herbal medicinal products, and current analytical techniques used for their detection.

Key words

herbal medicinal products - chemical adulterants - toxicity - analytical techniques - detection
 

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