Planta Med 2016; 82(09/10): 872-876
DOI: 10.1055/s-0042-102885
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Authors

  • Zhenzhen Zhang

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
  • Wenqiang Guo

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
  • Xueqian He

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
  • Qian Che

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
  • Tianjiao Zhu

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
  • Qianqun Gu

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
  • Dehai Li

    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Weitere Informationen

Publikationsverlauf

received 21. August 2015
revised 01. Februar 2016

accepted 03. Februar 2016

Publikationsdatum:
22. März 2016 (online)

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Abstract

Seven new 6-methylsaligenin derivatives, including the trimeric peniphenylanes A–B (12) and dimeric peniphenylanes C–G (37), together with four known biogenetically related compounds (811) were discovered from the extract of the deep-sea-derived fungus Penicillium fellutanum HDN14-323. The structures of the new compounds were established through extensive analysis. Their cytotoxic activity against HeLa, HL-60, and HCT-116 cell lines was evaluated, with compound 4 exhibiting the best activity against the HeLa cell line (IC50 = 9.3 µM).

Supporting Information