Planta Med 2016; 82(06): 559-572
DOI: 10.1055/s-0042-101943
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

A First Step in the Quest for the Active Constituents in Filipendula ulmaria (Meadowsweet): Comprehensive Phytochemical Identification by Liquid Chromatography Coupled to Quadrupole-Orbitrap Mass Spectrometry

Sebastiaan Bijttebier
1  University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium
,
Anastasia Van der Auwera
1  University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium
,
Stefan Voorspoels
2  Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology (SCT), Mol, Belgium
,
Bart Noten
2  Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology (SCT), Mol, Belgium
,
Nina Hermans
1  University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium
,
Luc Pieters
1  University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium
,
Sandra Apers
1  University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium
› Author Affiliations
Further Information

Publication History

received 21 August 2015
revised 07 December 2015

accepted 14 December 2015

Publication Date:
04 February 2016 (online)

Abstract

Filipendula ulmaria (meadowsweet) is traditionally used for the treatment of inflammatory diseases and as a diuretic and antirheumatic. Extracts of Filipendulae herba are on the market in the European Union as food supplements. Nevertheless, its active constituents remain to be revealed. During this study, the phytochemical composition of Filipendulae Ulmariae Herba was comprehensively characterised for the first time with two complementary generic ultrahigh-performance liquid chromatography-photodiode array-accurate mass mass spectrometry methods. Selective ion fragmentation experiments with a hybrid quadrupole-orbital trap mass spectrometer significantly contributed to compound identification: a total of 119 compounds were tentatively identified, 69 new to F. ulmaria. A rich diversity of phenolic constituents was detected and only a few non-phenolic phytochemicals were observed. Metabolisation and pharmacological studies should be conducted to investigate which of these constituents or metabolites there of contribute to the activity of F. ulmaria after oral intake.