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Hebamme 2016; 29(02): 80-85
DOI: 10.1055/s-0042-100876
Schwangerschaft
Fetale Programmierung
Hippokrates Verlag in Georg Thieme Verlag KG Stuttgart

Mütter zu gesunder Ernährung motivieren – Langzeitfolgen fürs Kind vorbeugen

Franziska Scheu
Ernährungswissenschaftlerin und angehende Hebamme, Karlsruhe
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Publikationsdatum:
26. April 2016 (online)

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Ein nicht eingestellter Diabetes mellitus in der Schwangerschaft erhöht das Risiko für das Kind, später an Diabetes Typ 2 zu erkranken. Hebammen spielen bei der Prävention eine Schlüsselrolle. Deshalb ist es wichtig, die Mechanismen der fetalen Programmierung bei Gestationsdiabetes zu verstehen. Eine frühe Ernährungstherapie der Mutter kann diabetogenen Stoffwechselstörungen beim Kind vorbeugen.

Dieser Beitrag basiert auf einer wissenschaftlichen Arbeit, die für den Bübchen Wissenschaftspreis für Hebammen 2015 eingereicht wurde.

 

  • Literatur

  • 1 Bantle JP, Wylie-Rosett J, Albright AL, Apovian M, Clark NG, Franz MJ, Hoogwerf BJ, Lichtenstein AH, Mayer-Davis E, Mooradian AD, Wheeler ML. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 2008; 31 (Suppl 1): 61-78
    Google Scholar
  • 2 Catalano PM, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S et al. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia 2006; 49: 1677-1685
    CrossrefGoogle Scholar
  • 3 Crume TL, Ogden L, West NA, Vehik KS, Scherzinger A, Daniels S, McDuffie R, Bischoff K, Hamman RF, Norris JM, Dabelea D. Association of exposure to diabetes in utero with adiposity and fat distribution in a multiethnic population of youth: the Exploring Perinatal Outcomes among Children (EPOCH) Study. Diabetologia 2010; 54: 87-92
    Google Scholar
  • 4 Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, Roumain J, Bennett PH, Knowler WC. Intrauterine exposure to diabetes conveys risks for type II diabetes and obesity: a study of discordant sibships. Diabetes 2000; 49: 2208-2211
    CrossrefGoogle Scholar
  • 5 Dabela D. The predisposition to obesity and diabetes in offspring of diabeticmothers. Diabetes Care 2007; 30 (Supp 2): 167-174
    Google Scholar
  • 6 Dörner G (a) Perinatal hormone levels and brain organization. In: Stumpf WE, Grant LD, (Hrsg.) Anatomical neuroendocrinology. Karger; Basel: 1975: 245-252
    Google Scholar
  • 7 Dörner G (b) Problems and terminology of functional teratology. Acta Biol Med Ger 1975; 34 (6): 1093-1095
    Google Scholar
  • 8 Dörner G, Plagemann A. Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity, and enhanced cardiovascularrisk in later life. Horm Metab Res 1994; 26: 213-221
    Artikel in Thieme ConnectGoogle Scholar
  • 9 EarlyNutrition Project. Long-term effect of early nutrition on later health. This project receives funding from the European Union Seventh Frame-work Programme (FP7/2007–2013) under grant agreement n° 289346 Internet: http://www.projectearlynutrition. eu/pdf/news/EN_factsheet_en_AL_290312.pdf (Stand:07.09.2013)
    Google Scholar
  • 10 Egeland GM, Meltzer SJ. Following in mother’s footsteps? Mother–daughter risks for insulin resistance and cardiovascular disease 15 years after gestational diabetes. 55 Diabetes Med 2010; 27: 257-265
    Google Scholar
  • 11 Elmadfa I. Ernährungslehre. 2. Auflage Verlag Eugen Ulmer GmbH&Co; Stuttgart: 2009
    Google Scholar
  • 12 EUFIC – The European Food Information Council. DIE GRUNDLAGEN 01/2009, Fakten über Vollkorn. Internet: http://www.eufic.org/article/de/expid/fakten-ueber-vollkorn/,2009 (Stand 22.12.2015)
    Google Scholar
  • 13 Fisher RE, Steele M, Karrow NA. Fetal programming of the neuroendocrine-immune system and metabolic disease. J Pregnancy 2012; 2012 792934
    Google Scholar
  • 14 Franke K, Harder T, Aerts L, Melchior K, Fahrenkrog S, Rodekamp E, Ziska T, Van Assche FA, Dudenhausen JW, Plagemann A. „Programming“ of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats. Brain Res 2005; 1031 (2): 276-283
    CrossrefGoogle Scholar
  • 15 Gillman MW, Rifas-Shiman S, Berkey CS, Field AE, Colditz GA. Maternal gestational diabetes, birth weight, and adolescent obesity. Pediatrics 2003; 111: e221-226
    CrossrefGoogle Scholar
  • 16 Godfrey KM, Gluckman PD, Hanson MA. Developmental orgins of metabolic disease: life course and intergenerational perspectives. Trends Endocrinol Metab 2010; 21: 199-205
    CrossrefGoogle Scholar
  • 17 Hivert MF, Sullivan LM, Fox CS, Nathan DM, D’Agostino RB S, Wilson PW, Meigs JB. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Mctab 2008; 93: 3165-3172
    Google Scholar
  • 18 Kautzky-Willer A, Bancher-Todesca D, Pollak A, Repa A, Lechleitner M, Weitgasser R. Gestationsdiabetes (GDM). Wien Klin Wochenschr 2012; 124 (Suppl 2): 58-65
    CrossrefGoogle Scholar
  • 19 King JC. Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr 2006; 26: 271-291
    CrossrefGoogle Scholar
  • 20 Kleinwechter H, Schäfer-Graf U, Bührer C et al. Gestationsdiabetes mellitus (GDM) – Diagnostik, Therapie u. Nachsorge – Praxisleitlinie der Deutschen Diabetes-Gesellschaft (DDG) und der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Journal:Diabetologie und Stoffwechsel, Herausgeber M. Kellerer, S. Matthaei, Thieme Verlag; 2014: S202-S213
    CrossrefGoogle Scholar
  • 21 Kleinwechter H, Schäfer-Graf U, Bührer C et al. Evidenzbasierte Leitlinie zu Diagnostik, Therapie u. Nachsorge, der Deutschen Diabetes Gesellschaft (DDG) und der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Herausgeber M. Kellerer, S. Matthaei 2011
    CrossrefGoogle Scholar
  • 22 Koletzko B, Brands B, Poston L, Godfrey K, Demmelmair H. Early nutrition programming of long-term health. Proc Nutr Soc 2012; 71(3): 371-378
    CrossrefGoogle Scholar
  • 23 Koletzko B (a) The power of programming: developmental origins of health and disease. Am J Clin Nutr 2011; 94: 1747S-2043S
    CrossrefGoogle Scholar
  • 24 Koletzko B, (b) Symonds ME, Olsen SF. Programming research: where are we and where do we go from here?. Am J Clin Nutr 2011; 94 (6 Suppl): 2036S-2043S
    CrossrefGoogle Scholar
  • 25 Lacroix et al. Maternal/Fetal determinants of Insulin resistance in women during pregnancy and in offspring over life. Curr Diab Rep 2013; 13 (2): 238-244
    CrossrefPubMedGoogle Scholar
  • 26 Lawlor DA, Fraser A, Lindsay RS, Ness A, Dabelea D, Catalano P, Smith GD, Sattar N, Nelson SM. Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia 2010; 53: 89-97
    CrossrefGoogle Scholar
  • 27 Metzger BE, Gabbe SG, Persson B et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010; 33: 676-682
    Google Scholar
  • 28 Plagemann A (a) Perinatal programming and functional teratogenesis: impact on body weight regulation and obesity. Clinic of Obstetrics 2005; 86 (5): 661-668
    Google Scholar
  • 29 Plagemann A (b) Fetale Programmierung und funktionelle Teratologie, Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen. (Ganten D, Ruckpaul W; Hrsg.) Springer; Berlin: 2005: 325-342
    CrossrefGoogle Scholar
  • 30 Plagemann A, Harder T, Rake A, Melchior K, Rittel F, Rohde W, Dorner G. Hypothalamic insulin and neuropeptide Y in the offspring of gestational diabetic mother rats. NeuroReport 1998; 4069-4073
    Google Scholar
  • 31 Ruemmele FM. Early programming effects of nutrition – life-long consequences?. Ann Nenceutr Metab 2011; 58 (Suppl 2): 5-6
    Google Scholar
  • 32 Schwartz MW, Woods SC, Porte D Jr., Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-671
    CrossrefPubMedGoogle Scholar
  • 33 Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers. Diabetes Care 1996; 18: 611-617
    Google Scholar
  • 34 WHO. Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation. Part 1: diagnosis and and classifications of diabetes melltitus. Geneva: World Health Organization and Department of Noncommunicable Disease Surveillance,Geneva,1999 Internet: http://whqlibdoc.who.int/hq/1999/who_ncd_ncs_99.2.pdf (Stand: 11.09.2013)
    Google Scholar