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CC BY-NC-ND 4.0 · The Arab Journal of Interventional Radiology 2021; 05(02): 082-087
DOI: 10.1055/s-0041-1742220
Original Article

Safety and Effectiveness of Transthoracic Core Needle Biopsy in a Newly Established Interventional Radiology Program in Tanzania

Authors

  • Erick M. Mbuguje 

    1   Department of Radiology and Imaging, Muhimbili University of Health and Allied Sciences (MUHAS), Dar Es Salaam, Tanzania

  • Jared M. Alswang

    2   Harvard Medical School, Boston, Massachusetts, United States

  • Ivan Rukundo

    1   Department of Radiology and Imaging, Muhimbili University of Health and Allied Sciences (MUHAS), Dar Es Salaam, Tanzania

  • Azza Naif

    1   Department of Radiology and Imaging, Muhimbili University of Health and Allied Sciences (MUHAS), Dar Es Salaam, Tanzania

  • Fabian M. Laage Gaupp

    3   Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, United States

  • Vijay Ramalingam

    4   Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

  • Murray Asch

    5   Diagnostic Imaging, Lakeridge Health Corporation, Oshawa, Ontario, Canada
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Abstract

Background Transthoracic core needle biopsy (TTCNB) became a routinely offered procedure in Tanzania in October 2018. This study evaluates the safety and effectiveness of establishing a TTCNB program in a resource-limited setting.

Methodology A single center, prospective, observational cohort study was conducted at Muhimbili National Hospital on 90 patients who underwent computed tomography-guided TTCNB from October 2018 to May 2021. Patient and procedural data, including demographic information, complications, pathology results, and clinical outcomes, were stored in a Research Electronic Data Capture (REDCap) database. Follow-up was conducted at 4 weeks postprocedure by phone. Descriptive analysis was performed using Statistical Package for Social Sciences.

Results A total of 90 patients underwent TTCNB. Seven samples were lost or never processed. In total, 68/83 (81.9%) of processed samples were diagnostic, with 89.7% (n = 61) classified as malignant and 10.3% (n = 7) classified as benign. Overall, 82.4% (n = 56) were classified as primary malignancies, 7.4% (n = 5) as metastatic malignancies, 5.9% (n = 4) as benign tumors, and 4.4% (n = 3) as infectious. Reasons for nondiagnostic samples were crashed/insufficient samples in 53.3% (n = 8) and nonspecific chronic inflammation in 46.7% (n = 7). Minor (Society of Interventional Radiology [SIR] class A and B) complications occurred in 8 cases (8.9%), while there was 1 (1.1%) major complication (SIR class F). A total of 44/90 (48.9%) patients could be reached for follow-up at 4 weeks postprocedure. In addition, 31/44 (70.5%) of these patients had a diagnosis of malignancy. Of these, 20 received chemotherapy, 8 died prior to receiving any treatment, 2 declined any further medical or surgical intervention, and 1 was treated with surgical excision and adjuvant chemotherapy.

Conclusion Although recently introduced in Tanzania, TTCNB has been performed with 81.9% diagnostic accuracy and a complication rate comparable to existing literature.

Keywords

cancer - core needle biopsy - transthoracic

Note

Previous poster presentation: Society of Interventional Radiology (SIR) annual meeting, March 20–26, 2021.


This study received ethics approval by the hospital institutional review board (IRB).




Publikationsverlauf

Artikel online veröffentlicht:
02. Februar 2022

© 2022. The Pan Arab Interventional Radiology Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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