Recurrent Blistering Skin Lesions and Reversible Monocular Abducens Paralysis in a Patient with CD59 Deficiency

Abstract

Congenital CD59 deficiency is an autosomal recessive disease characterized by mild-to-moderate chronic intravascular hemolysis, relapsing demyelinating peripheral neuropathies, and recurrent ischemic central nervous system strokes. We report a 2-year-old Turkish girl with a history of two episodes of Guillain-Barré syndrome-like acute weakness, reversible monocular abducens paralysis, and recurrent blistering skin lesions during periods of upper respiratory tract infections. Reversible monocular abducens palsy and recurrent blistering skin lesions have not been reported previously in cases of congenital CD59 deficiency.

Keywords

congenital CD59 deficiency - relapsing demyelinating peripheral neuropathies - blistering skin lesions - reversible monocular abducens palsy

Declaration of Competing Interest

All authors have read the manuscript and agreed with its content and stated that there is no conflict of interest.

Data Availability Statement

Any additional data required are available on request.

Publication History

Received: 09 November 2020

Accepted: 30 December 2020

Article published online:
28 January 2022

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