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CC BY 4.0 · Eur J Dent 2023; 17(01): 070-075
DOI: 10.1055/s-0041-1742132
Original Article

The Effect of Periodontal Therapy on the Level of MMP-8 in Patients with Chronic Periodontitis

Mirlinda Sopi 
1   Department of Periodontology and Oral Medicine, Dentistry School, University of Pristina, Pristina, Kosovo
,
Ferit Koçani 
2   Department of Dental Pathology and Endodontics, Dentistry School, University of Pristina, Pristina, Kosovo
,
Merita Bardhoshi 
3   Department of Oro-Maxillofacial Surgery, University of Medicine, Tirana, Tirana, Albania
,
Kastriot Meqa 
4   Department of Periodontology and Oral Medicine, Dentistry School, University of Pristina, Pristina, Kosovo
› Author Affiliations Funding None.
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Abstract

Objective The complete removal of bacterial plaque and their endotoxins in deeper areas of periodontal pockets is often difficult to achieve with conventional methods such as periodontal pocket curettage. An alternative to these methods that recently gained popularity in periodontology is the diode laser, with its antibacterial effect, angiogenesis promotion as advantages.

Materials and Methods This study included 100 patients diagnosed with chronic periodontitis, with periodontal pockets up to 6 mm, and who were divided into two groups: patients treated with basic therapy and diode laser application, and patients treated with basic therapy and with flap surgery. The clinical periodontal evaluation was done before the treatment and 6 months after the treatment. Evaluation of matrix metalloproteinase (MMP)-8 as an inflammatory indicator in gingival exudate was done with dipstick immunoassay test before the treatment and 6 months later.

Results This study showed a more pronounced improvement of periodontal clinical parameters, as well as a decrease in MMP-8 values in gingival exudate in the laser-treated group compared with the surgically treated group.

Conclusion The results of this study are encouraging for the use of the diode laser as a noninvasive method in the treatment of periodontal pathologies.

Keywords

chronic periodontitis - diode laser - periodontal flap surgery - matrix metalloproteinase-8

Authors' Contributions

M.S., F.K., and K.M. conceptualized the study; methodology, formal analysis, investigation, resources, data curation, writing—original draft preparation, and funding acquisition were done by M.S.; software operated by K.M.; validation was done by M.S., F.K., M.B., and K.M.; writing—review and editing was done by F.K. and K.M.; visualization by K.M.; supervision by F.K. All authors have read and agreed to the published version of the manuscript.


Ethical Approval

This study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Ethics Committee of the Faculty of Medicine of the University of Prishtina (protocol code 3833, May 12, 2017).


Informed Consent

Informed consent was obtained from all subjects involved in the study.




Publication History

Article published online:
16 February 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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