Abstract
As many as 500,000 cholecystectomies are performed per year in the United States.
Frail patients are at higher risk from cholecystectomy, with reported postoperative
complication and mortality rates as high as 31 and 5% in patients older than 75 years.
Percutaneous cholecystostomy drainage is commonly employed in high-risk patients with
cholecystitis, with over 12,000 cases performed annually. Cholecystostomy, however,
is not a definitive treatment, with up to 30% of patients having a recurrent episode
of cholecystitis within 4 months after tube removal. Gallbladder cryoablation has
emerged as a minimally invasive procedure that achieves transmural gallbladder wall
necrosis in a single session resulting in gallbladder fibrosis and involution. Early
clinical data have been promising, with reported technical success of 86% and clinical
success of 100% at up to 500 days of follow-up. Several challenges and unknowns remain,
however, including optimal patient selection and procedural technique, the potential
need for adjunct procedures to occlude the cystic duct, the implications of the immunostimulatory
effects of cryoablation, and the impact of the presence of gallstones on outcomes.
This article reviews the rationale behind gallbladder cryoablation, updates early
clinical outcomes, and discusses the challenges that remain for the adoption of the
technique for the treatment of benign gallbladder disease.
Keywords
gallbladder - cryoablation - cholecystitis
