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CC BY-NC-ND 4.0 · J Lab Physicians 2022; 14(01): 047-056
DOI: 10.1055/s-0041-1741443
Original Article

Analysis of Prediagnostic Circulating Levels of Gonadotropins and Androgens with Risk of Epithelial Ovarian Cancer

Deepak Parchwani
1   Department of Biochemistry, All India Institutes of Medical Sciences, Rajkot – 360001, Gujarat, India
,
Sagar Jayantilal Dholariya 
1   Department of Biochemistry, All India Institutes of Medical Sciences, Rajkot – 360001, Gujarat, India
,
Sohil Takodara
2   Department of Biochemistry, Geetanjali Medical College, Udaipur, Rajasthan, India
,
Ragini Singh
1   Department of Biochemistry, All India Institutes of Medical Sciences, Rajkot – 360001, Gujarat, India
,
Vivek Kumar Sharma
3   Department of Physiology, All India Institutes of Medical Sciences, Rajkot, Gujarat, India
,
Alpana Saxena
4   Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, New Delhi, India
,
Digishaben D. Patel
3   Department of Physiology, All India Institutes of Medical Sciences, Rajkot, Gujarat, India
,
Madhuri Radadiya
5   Department of Radiology, Pandit Dindayal Upadhyay Medical College, Rajkot, Gujarat, India
› Institutsangaben Funding We did not receive any funding for this research work.
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Abstract

Background Prevailing experimental and epidemiological evidence supports the role of circulating endogenous sex steroid hormones in the pathogenesis of ovarian carcinogenesis by dysregulation of cell differentiation, proliferation, and apoptosis but is scarce and inconclusive.

Objectives This article evaluates the role of circulating levels of gonadotropins (follicle-stimulating hormone [FSH], luteinizing hormone [LH]) and androgens (testosterone, dehydroepiandrosterone-sulfate [DHEA-S]) for the risk of epithelial ovarian cancer in a case–control approach using samples collected in advance of clinical diagnosis.

Materials and Methods A total of 100 epithelial ovarian cancer (EOC) patients and 100 healthy female controls were consequently enrolled in this hospital-based case–control study. Serum FSH, LH, testosterone, and DHEA-S were measured based on the principle of electrochemiluminescence immunoassay. Suitable descriptive statistics were used for different variables.

Results Median values of FSH (58.9 vs. 45.5 IU/L, p = 0.02) and DHEA-S (163.43 vs. 142.2 ug/dL, p = 0.03) were significantly high in EOC patients compared with controls. Conditional logistic regression was used to estimate the odds ratio (OR) across increasing thirds of FSH and DHEA-S concentrations, and the results revealed that the highest third tertile of FSH (> 72.6 IU/L; OR = 3.0, confidence interval [CI] = 1.24–7.29, p trend = 0.04) and DHEA-S (> 194.2 ug/dL; OR = 3.8, CI = 1.26–11.61, p trend = 0.03) were significantly associated with increased risk of ovarian cancer in postmenopausal and premenopausal women, respectively. The statistically significant trend observed for FSH in postmenopausal women, remained only for the subgroup with menopause duration greater than 10 years (OR = 5.9, CI = 1.33–26.66, p trend = 0.04). FSH and DHEA-S concentrations and ovarian cancer risk were internally consistent with groups defined by oral contraceptive pill use, hormone replacement therapy, and smoking. However, no evidence was found for the association between serum LH and testosterone level with the occurrence of ovarian tumorigenesis.

Conclusion Prediagnostic circulating concentration of FSH and DHEA-S unveiled a significant positive association with augmented risk of EOC, thus might serve as a predictive marker for the susceptibility to ovarian carcinogenesis and should be added in the screening profile of EOC for early recognition and scheduling necessary interventions/management strategies.

Keywords

epithelial ovarian cancer - follicle-stimulating hormone - dehydroepiandrosterone-sulfate


Publikationsverlauf

Artikel online veröffentlicht:
18. Januar 2022

© 2022. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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