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DOI: 10.1055/s-0041-1740441
Classical Hodgkin Lymphoma Presenting as Cutaneous and Soft Tissue Mass Lesion: An Enigmatic Presentation Posing a Diagnostic Challenge—A Case Report and Review of Literature
Abstract
Hodgkin lymphoma (HL) is primarily a nodal disease. Cutaneous involvement of HL as a presenting feature is extremely rare. Skin involvement is usually seen as a metachronous involvement in the course of disease and is associated with poor prognosis. Primary skin and soft tissue involvement can be construed as nonhematological, inflammatory, or infective etiology. We report a 14-year-old girl with fever, weight loss, lymphadenopathy, and multiple papular lesions over the right chest wall as initial manifestation of HL, posing a diagnostic challenge. In view of stage IVBE, patient was managed with intensive chemotherapy regimen and is currently free of disease at 6 months of follow-up.
Declaration of Patient Consent
The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.
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Publication History
Article published online:
03 February 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Marafioti T, Hummel M, Foss HD. et al. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 2000; 95 (04) 1443-1450
- 2 Guermazi A, Brice P, de Kerviler EE. et al. Extranodal Hodgkin disease: spectrum of disease. Radiographics 2001; 21 (01) 161-179
- 3 Goyal S, Biswas A, Puri T, Gupta R, Muzumder S, Julka PK. Different faces of cutaneous Hodgkin's disease. Indian J Dermatopathol Diagn Dermatol 2014; 1: 79
- 4 Isao M, Masanori D, Masatoshi F, Hirokuni T. Cutaneous involvement in Hodgkin's disease. Int Med J Stage 2007; 46: 73-74
- 5 Rubenstein M, Duvic M. Cutaneous manifestations of Hodgkin's disease. Int J Dermatol 2006; 45 (03) 251-256
- 6 Khawandanah M, Kraus T, Cherry M. Refractory classical Hodgkin lymphoma presenting with atypical cutaneous involvement and diagnosis of ZZ phenotype alpha-1 antitrypsin deficiency. Case Rep Hematol 2014; 2014: 642868
- 7 Dhull AK, Soni A, Kaushal V. Hodgkin's lymphoma with cutaneous involvement. BMJ Case Rep 2012; 2012: bcr2012007599
- 8 White RM, Patterson JW. Cutaneous involvement in Hodgkin's disease. Cancer 1985; 55 (05) 1136-1145
- 9 Jurisić V, Bogunović M, Colovic N, Colović M. Indolent course of the cutaneous Hodgkin's disease. J Cutan Pathol 2005; 32 (02) 176-178
- 10 Howlader N, Noon AM, Krapcho M. et al. Eds. SEER Cancer Statistics Review, 1975–2017. National Cancer Institute; Bethesda, https://seer.cancer.gov/csr/1975_2017 MD Accessed July 10, 2021