Journal of Pediatric Neurology 2022; 20(02): 138-141
DOI: 10.1055/s-0041-1740363
Case Report

Vanishing White Matter Disease Presenting as Acute Febrile Encephalopathy: Case Report

Jyotindra Narayan Goswami
1   Department of Pediatrics, Army Hospital (Research & Referral), New Delhi, India
,
Shijith K.P
2   Department of Radiodiagnosis, Army Hospital (Research & Referral), New Delhi, India
,
Ashish Kumar Simalti
1   Department of Pediatrics, Army Hospital (Research & Referral), New Delhi, India
,
Saroj Kumar Patnaik
1   Department of Pediatrics, Army Hospital (Research & Referral), New Delhi, India
› Author Affiliations
Funding None.

Abstract

A 3.5-year-old male child patient with mild developmental delay presented with history of acute onset fever, encephalopathy, and dyskinesia. The patient was investigated for common etiologies and was managed supportively. His neuroimaging was suggestive of vanishing white matter (VWM) disease which was confirmed by clinical exome sequencing. The child had an eventful hospital stay followed by near-total recovery after 4 weeks. The case attempts to sensitize readers about the current perspectives pertaining to VWM disease.

Authors' Contributions

J.N.G.: Case management, literature review, initial draft manuscript preparation and approval of final manuscript.


S.K.P.: Interpretation of neuroimaging, literature review, and approval of final manuscript.


A.S.: Case management, literature review, and initial draft manuscript preparation.


S.K.P.: Clinician-in-charge, critical review of manuscript for important intellectual content, and final approval of the version to be published.




Publication History

Received: 15 August 2019

Accepted: 18 September 2019

Article published online:
07 December 2021

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