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Inguinal Superficial CD34-Positive Fibroblastic Tumor. Case Report and Literature ReviewArticle in several languages: español | English Funding The present research has not received any specific grant from public, commercial, or non-profit agencies.
Superficial cluster of differentation 34 (CD34)-positive fibroblastic soft-tissue tumor is a rare, low-frequency tumor, characterized histologically by marked pleomorphism, low mitotic activity, and diffuse immunoreactivity for CD34. It may behave like a mesenchymal tumor of intermediate malignancy. There are only 52 cases published in the literature. We present the case of a 31-year-old patient with a long progressive and painful growth of a soft-tissue lesion in the left inguinal region. The mass was biopsied and, with the suspicion of a superficial CD34-positive fibroblast tumor, it was subsequently treated with an enlarged resection of the lesion and covering the skin defect with a local V-Y advancement flap, with a satisfactory evolution in the postoperative follow-up. The pathology report confirmed the diagnostic suspicion of a tumor with strong reactivity for CD34, with tumor protein p53 in 60% to 70%, antigen Ki67 in less than 15%, without loss of nuclear INI-1 protein, and with negativity for CD31, CD163, AE1AE3, CAM5.2, EMA, CD30, progestin receptors, S100 protein and desmin, with negative borders.
Level of evidence IV.
KeywordsCD34 - immunohistochemistry - mesenchymal tumors - superficial sarcoma - fibroblastic tumor - cytology
Received: 15 May 2020
Accepted: 06 August 2021
22 December 2021 (online)
© 2021. Sociedad Chilena de Ortopedia y Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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