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CC BY-NC-ND 4.0 · Journal of Coloproctology 2022; 42(01): 054-058
DOI: 10.1055/s-0041-1739453
Original Article

Tissue Factor Expression in Colorectal Adenocarcinoma: Association with Angiogenesis and Clinical and Pathological Aspects

Lúcio Sarubbi Fillmann 
1   PhD in Medicine and Health Sciences from PUC-RS and Professor in the Department of Surgery at PUC-RS School of Medicine, Porto Alegre, RS, Brazil
,
Laura Pinho Fillmann 
2   Student of the Undergraduate Course in Medicine at PUC-RS, Porto Alegre, RS, Brazil
,
Leonardo Zarpelon de Oliveira 
2   Student of the Undergraduate Course in Medicine at PUC-RS, Porto Alegre, RS, Brazil
,
Henrique Sarubbi Fillmann 
3   PhD from UFRGS and Professor at the School of Medicine at PUC-RS, Professor at the Department of Surgery at the School of Medicine at PUC-RS, Porto Alegre, RS, Brazil
,
Gustavo Franco Carvalhal 
4   PhD in Urology from USP and Professor in the Department of Surgery at the PUC-RS School of Medicine, Porto Alegre, RS, Brazil
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Abstract

Introduction Tissue factor (TF) expression has been described in various neoplasms and was correlated with angiogenesis and metastases.

Objectives To describe TF expression in colorectal cancers, correlating it with microvessel density and clinical and pathological variables.

Methods Immunohistochemistry was used to determine TF expression and microvessel density. The Student t-test was used to compare high and low TF expression with microvessel density and with age. The chi-squared test was used for other comparisons, and Kaplan-Meier curves were used for survival analyses.

Results Forty-three patients were operated with curative intent. Their mean age was 58.1 ± 12.6 years old, and 62.8% were male. The rectum was the most common location (60,4%), and most tumors reached the serosa and peri-intestinal fat (72.1%). Lymph nodes were positive in 46.5%, and 72.1% of the tumors were moderately differentiated adenocarcinomas. Death occurred in 27.6 ± 12.8 months in 51.1% of the patients who had recurrence. Tissue factor expression was intense in 88.4%. There was a positive correlation between TF expression and microvessel density (p = 0.02), and between TF and older age (p < 0.01). There was no correlation between TF expression and other variables (gender, histological type, penetration into the intestinal wall, and lymphatic and systemic metastases). Tissue factor expression did not correlate with survival.

Conclusion Tissue factor expression correlated with increased microvessel density and older age. Further studies are necessary to ascertain the clinical relevance of TF in colorectal cancer.

Keywords

tissue factor - angiogenesis - colorectal adenocarcinoma

The present study was performed at Colproctology Service of the Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.




Publication History

Received: 07 June 2021

Accepted: 06 September 2021

Article published online:
31 January 2022

© 2022. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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