Evaluation of Passive Permeability of Withania somnifera Plant Extracts

Phytomedicine has seen a large push to not only corroborate ethnobotanical therapeutic use, but to optimize and enhance bioavailability of specific compounds within plants for use in modern day medicine. Many medicinal plants produce compounds that once purified, exhibit low permeability and thus poor bioavailability promoting doubt around the actual efficacy of these components as therapeutics. Withania somnifera, commonly known as Ashwagandha, is a powerful medicinal plant used to combat insomnia, inflammation, and neurodegenerative disorders. While permeability profiles have been determined for specific bioactive compounds in W. somnifera, including withanone [1] and withanolide A [2], little research has been published investigating potential additive and synergistic effects of whole extract preparations. This study will leverage an LC-MS based metabolomics analytical approach to investigate multiple extraction techniques, as well as the effect of stomach and intestinal fluid pre-incubations on the passive permeability of compounds and extracts from W. somnifera using the parallel artificial membrane permeability assay (PAMPA) [3].

Publikationsverlauf

Artikel online veröffentlicht:
13. Dezember 2021

• References

• 1 Singh et al. Drug Dev. Res. 2018, 79, 339-351.
• 2 Singh et al. J. Ethnopharmacol. 2021, 270, 113819.
• 3 Petit et al. Planta Med. 2016, 82, 424-431.