Planta Med 2021; 87(15): 1279
DOI: 10.1055/s-0041-1736876
Abstracts
8. Poster Contributions
8.5 Translational natural product pharmacology

Neuroprotective and antidiabetic activities of Thymus capitellatus aqueous extracts

C. Martins-Gomes
1   Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD) Vila Real, Portugal
2   Food and Wine Chemistry Lab., Chemistry Research Centre - Vila Real (CQ-VR), UTAD, Quinta de Prados; 5001-801 Vila Real, Portugal.
,
F.M. Nunes
2   Food and Wine Chemistry Lab., Chemistry Research Centre - Vila Real (CQ-VR), UTAD, Quinta de Prados; 5001-801 Vila Real, Portugal.
,
A.M. Silva
1   Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD) Vila Real, Portugal
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Authors acknowledge funding from the Portuguese Science and Technology Foundation, and NORTE 2020, through European and National funds, under the projects UIDB/04033/2020 (CITAB), UIDB/00616/2020 (CQ-VR), as well as the PhD grant to C. M.-G. (SFRH/BD/145855/2019).
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Halt biodiversity loss is one of the main challenges present nowadays. Either due to climatic changes or anthropogenic activities, a warning number of species have been listed as threatened for a possible risk of extinction. For these reasons and due to particular edaphoclimatic conditions, Thymus capitellatus, a near-threatened species, can only be found on Portugal’s southwest shore. Aqueous decoction (AD) extracts obtained from T. capitellatus aerial parts were analyzed to ascertain its phytochemical composition and evaluated for their neuroprotective and antidiabetic activities. HPLC-DAD analysis of the AD extracts revealed rosmarinic acid, salvianolic acids, and glycosidic derivatives of apigenin, luteolin, and quercetin, as the main components of this extract. Using acetylcholinesterase and tyrosinase inhibition assay it was observed that the extracts show potential neuroprotective effect. Regarding antidiabetic activity, selective inhibition of α-glucosidase was observed, in contrast with a low inhibition of α-amylase, showing a potential for reducing intestinal sugar absorption.

These results provide a new insight into T. capitellatus possible applications in pharmaceutical and nutraceutical industries and thus increasing the interest in its preservation.



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Artikel online veröffentlicht:
13. Dezember 2021

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