Planta Med 2021; 87(15): 1266
DOI: 10.1055/s-0041-1736835
Abstracts
8. Poster Contributions
8.3 Antiinfectives and Epidemiology

Identification of anti-parasitic agents in Cichorium intybus.

A Valente
1   Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
,
M de Roode
2   Sensus b.v., RA Roosendaal, the Netherlands
,
M Peña-Espinoza
3   Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile
,
L Bornancin
4   Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 223, 2800, Kongens Lyngby
,
H Simonsen
4   Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 223, 2800, Kongens Lyngby
,
S Thamsborg
1   Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
,
A Williams
1   Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
› Institutsangaben
Funding (This work was funded by the Danish Council for Independent Research (Grant DFF–6111-00394). Fractionation and purification of compounds were further supported by the Green Development and Demonstration Program (GUDP) (Project No. 34009-17-1220). MPE was supported by CONICYT Chile (FONDECYT Postdoctorado #3170875).)
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As the focus on animal welfare and environmental hazards increases, organic farming becomes more prominent. With the prolonged grassing time, cattle now have a much higher exposure to gastrointestinal (GI) parasites, which affects animal growth[1], resulting in markedly economic consequences for the farmer. Long periods on grass also mean long periods of anti-parasitic treatment, leading to a higher risk of resistance. As the treatment of parasites in cattle currently relies on few anti-parasitic drugs, the resistance is increasing, and it is crucial that we find alternative treatment methods. Cattle grazing on chicory (Cichorium intybus) has lower Ostertagia ostertagi infection levels, indicating that chicory could be a promising anthelmintic agent [2]. Until recently, the responsible, active compounds were unknown. Five chicory cultivar were investigated for anthelmntic activity using a model in vitro system based on the mortality of the swine nematode Ascaris suum exposed to chicory extracts. With a combination of metabolic networking and bio-guided fractionation, this study conclud that a combination of sesquiterpene lactones (SL's) are the compounds associated with the anti-parasitic activity of chicory. Five SL's were purified and identified through NMR. The synergistic analysis further identified 8-deoxylactucin as the main active compound, acting synergistically with the other SL's. Metabolic research is devoted to determining the lethal mechanism of action of anti-parasitic SL's in Caenorhabditis elegans.



Publikationsverlauf

Artikel online veröffentlicht:
13. Dezember 2021

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