Planta Med 2021; 87(15): 1246
DOI: 10.1055/s-0041-1736770
Abstracts
3. Short Lectures

Phyllobilins – ubiquitous natural products with pharmacologically relevant activities

C. Karg
1   Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich
,
P. Wang
1   Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich
,
A.M. Vollmar
1   Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich
,
S. Moser
1   Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich
› Author Affiliations

Funding from the German Research Foundation (DFG, Project ID 448289381 to S.M.) is gratefully acknowledged.
 

Phyllobilins are a group of plant-derived bilin-type linear tetrapyrroles, which are generated in the process of chlorophyll degradation. Despite the visibility this biochemical pathway, the as well as the biochemical players involved have remained undetected for a very long time. Only 30 years ago was the first phyllobilin isolated and characterized by spectroscopic methods,which set the stage for the discovery of a variety of phyllobilins with different structural modifications depending on the plant species. Phyllobilins have primarily been regarded as products of a detoxification pathway employed by plants to get rid of phototoxic chlorophyll. Therefore, they have been overlooked as natural product class in terms of a biological role or pharmacological activity of their own. [1] A change of this paradigm, however, is long overdue.

For the first time, we show important pharmacological activities of phyllobilins as ingredients of medicinal plants, comprising potent antioxidative activities,[2] anti-inflammatory activities,[3] and activities on cancer cells.[4] This research sets the stage to systematically investigate the occurrence of phyllobilins and their roles as important phytochemicals.



Publication History

Article published online:
13 December 2021

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