CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2021; 42(04): 390-393
DOI: 10.1055/s-0041-1736679
Case Report with Review of Literature

A Rare Occurrence of Scalp Metastasis in Hepatocellular Carcinoma: Case Report

Samreen Javed Chaudry
1   Department of Clinical & Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan
,
Fajar Rafi Ranjha
1   Department of Clinical & Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan
,
Sumera Butt
1   Department of Clinical & Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan
,
Samaha Nawaz
1   Department of Clinical & Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan
› Author Affiliations
Funding None.

Abstract

Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy and the fifth most common cancer worldwide. Extrahepatic spread in this type of cancer is most commonly seen in the lungs and lymph nodes and less commonly in the skeletal system. Skull metastases are exceedingly rare, with an incidence of 0.5 to 1.6% reported to date. We report a similar case of a middle-aged Asian male patient with parietal scalp swelling that was initially diagnosed as meningioma. Surgical resection was performed at a local facility. The abdominal computed tomography scan did not reveal any primary or metastatic lesion. After much deliberation, multiparametric magnetic resonance imaging was requested that showed multiple lesions in the liver. Metastatic scalp lesion should be considered a differential diagnosis in HCC regardless of liver symptoms.



Publication History

Article published online:
26 November 2021

© 2021. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Fukutomi M, Yokota M, Chuman H. et al Increased incidence of bone metastases in hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2001; 13 (09) 1083-1088
  • 2 Kuhlman JE, Fishman EK, Leichner PK, Magid D, Order SE, Siegelman SS. Skeletal metastases from hepatoma: frequency, distribution, and radiographic features. Radiology 1986; 160 (01) 175-178
  • 3 Choi HJ, Cho BC, Sohn JH. et al Brain metastases from hepatocellular carcinoma: prognostic factors and outcome: brain metastasis from HCC. J Neurooncol 2009; 91 (03) 307-313
  • 4 Jiang XB, Ke C, Zhang GH. et al Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors. BMC Cancer 2012; 12: 49
  • 5 Rahbari NN, Mehrabi A, Mollberg NM. et al Hepatocellular carcinoma: current management and perspectives for the future. Ann Surg 2011; 253 (03) 453-469
  • 6 Seinfeld J, Wagner AS, Kleinschmidt-DeMasters BK. Brain metastases from hepatocellular carcinoma in US patients. J Neurooncol 2006; 76 (01) 93-98
  • 7 Yoshida D, Chen MN, Awaya S, Nakazawa S. Cranial metastasis of hepatocellular carcinoma in a female–case report. Neurol Med Chir (Tokyo 1993; 33 (12) 839-844
  • 8 Hsieh CT, Sun JM, Tsai WC, Tsai TH, Chiang YH, Liu MY. Skull metastasis from hepatocellular carcinoma. Acta Neurochir (Wien 2007; 149 (02) 185-190
  • 9 Kanda M, Tateishi R, Yoshida H. et al Extrahepatic metastasis of hepatocellular carcinoma: incidence and risk factors. Liver Int 2008; 28 (09) 1256-1263
  • 10 Uchino K, Tateishi R, Shiina S. et al Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors. Cancer 2011; 117 (19) 4475-4483
  • 11 Subasinghe D, Keppetiyagama CT, Sudasinghe H, Wadanamby S, Perera N, Sivaganesh S. Solitary scalp metastasis - a rare presentation of hepatocellular carcinoma. Ann Surg Innov Res 2015; 9: 4
  • 12 Shim YS, Ahn JY, Cho JH, Lee KS. Solitary skull metastasis as initial manifestation of hepatocellular carcinoma. World J Surg Oncol 2008; 6: 66
  • 13 McIver JI, Scheithauer BW, Rydberg CH, Atkinson JL. Metastatic hepatocellular carcinoma presenting as epidural hematoma: case report. Neurosurgery 2001; 49 (02) 447-449