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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2021; 42(06): 595-598
DOI: 10.1055/s-0041-1736431
Brief Communication

Hairy Cell Leukemia: Morphological and Immunophenotypic Characteristics of Seven Cases and Cyclin D1 Expression

Shruti Neelamegam Ramesh
1   Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
,
Somanath Padhi 
1   Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
,
Amit K. Adhya
1   Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
,
Ashutosh Panigrahi
2   Department of Medical Oncology/Hematology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
,
Prabodha K. Das
2   Department of Medical Oncology/Hematology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
,
Susama Patra
1   Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
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Funding None.
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Abstract

Aberrant immunophenotypic expression in hairy cell leukemia (HCL), both at medullary and extramedullary sites, is not uncommonly reported in literature. Cyclin D1 positivity in HCL may mimic mantle cell lymphoma (MCL) morphologically, especially in the presence of aberrant CD5 immunopositivity, requiring BRAFV600E mutation and/or CCND1 gene testing for confirmation. Here, we describe seven cases of HCL with clinicomorphological and immunophenotypic characteristics with an emphasis on cyclin D1 expression using immunohistochemistry (IHC) with a brief comprehensive literature review. We suggest that cyclin D1 positive HCL may be a distinct subtype which requires further immunophenotypic and molecular characterization for accurate diagnosis and planning of definitive therapy.

Keywords

hairy cell leukemia - trephine biopsy - translocation - therapy

Authors' Contributions

S.N.: data collection and analysis, literature review, writing of the first manuscript draft. S.P.: conceptual design, diagnosis, data analysis, literature review, review, and editing of manuscript. A.K.A. and S.P.: interpretation of data, diagnosis, and review of manuscript for intellectual contents. A.P. and P.K.D.: management of cases and review of manuscript for intellectual content.


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Publication History

Article published online:
30 December 2021

© 2021. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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