Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study

Vasanthapriya Janarthanan; Kulasekaran Nadhamuni; Sibhithran Rajakumar; Elamparidhi Padmanaban; Umamageswari Amirthalingam; Yashkumar Achantani

doi:10.1055/s-0041-1736402

Indian Journal of Radiology and Imaging, Table of Contents

CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2021; 31(03): 596-600
DOI: 10.1055/s-0041-1736402

Original Article

Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study

Vasanthapriya Janarthanan

¹Department of Radiology and Medical Imaging, Sri Venkateshwaraa Medical College Hospital & Research Centre, Puducherry, India

,

Kulasekaran Nadhamuni

²Department of Radio-Diagnosis, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India

,

Sibhithran Rajakumar

²Department of Radio-Diagnosis, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India

,

Elamparidhi Padmanaban

²Department of Radio-Diagnosis, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India

,

Umamageswari Amirthalingam

²Department of Radio-Diagnosis, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India

,

Yashkumar Achantani

³Rajsheel Diagnostics, Dabra, Gwalior, India

› Author Affiliations

Abstract

Context Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons ratio are useful to differentiate PSP from other PD patients.

Aims The study aimed to detect sensitivity and specificity of magnetic resonance Parkinsonism index in differentiating PSP from PD.

Settings and Design It was a retrospective case–control study conducted in Sri Manankula Vinayagar Medical College, Puducherry, during the period of January 2018 to June 2019.

Materials and Methods The 87 subjects, who were diagnosed and grouped into three categories (PSP, PD, and control) after performing magnetic resonance imaging brain, were reviewed. The parameters like the area of Pons and midbrain, width of MCP and SCP, P/M, M/P, and MRPI were calculated.

Statistical Analysis One-way ANOVA and Chi-square test was used. The sensitivity, specificity, diagnostic accuracy, and cut-off values obtained with receiver operating characteristic curve analysis were determined.

Results The mean age of presentation was approximately 75 years with male predominance. The cut-off value of MRPI obtained in this study was 13.4 with 100% sensitivity and specificity. Even though M/P ratio was found to be statistically significant among PSP patients; cut-off value was not obtained.

Conclusion MRPI was concluded as the better tool in diagnosing PSP compared with the M/P ratio. Hence the combined qualitative as well as quantitative measurement of MRPI will increase the diagnostic accuracy of PSP.

Keywords

magnetic resonance Parkinsonism index - midbrain/pons ratio - progressive supranuclear palsy - Parkinson's disease

Full Text

References

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