Vitamin D Supplementation in Sarcoidosis: A Double-Edged Sword

Abstract

Sarcoidosis is complicated by disordered vitamin D and calcium metabolism, which has important implications on disease activity and bone health. Although the majority of the patients with sarcoidosis are typically deficient in 25-hydroxyvitamin D, repletion of vitamin D is controversial in light of the hypercalcemia risk. Presently, there are no clear guidelines regarding vitamin D supplementation as a part of osteoporosis prevention in patients with vitamin D deficiency and sarcoidosis. We report a patient with sarcoidosis who presented with severe hypercalcemia following vitamin D supplementation and review the debated role of vitamin D supplementation in vitamin D-deficient sarcoid patients.

Keywords

Sarcoidosis - vitamin D deficiency - hypercalcemia

Note

Informed consent was obtained from all individual participants included in the study. All procedures performed in the study involving human participants were in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Publikationsverlauf

Artikel online veröffentlicht:
24. Oktober 2021

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