CC BY 4.0 · Pharmaceutical Fronts
DOI: 10.1055/s-0041-1736233
Review

Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

Xiao-Long Ma
1  State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China
,
Yu-Han Wang
1  State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China
,
Jin-Hua Shen
1  State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China
,
Yi Hu
1  State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China
› Author Affiliations
Funding This work was financially supported by the National Natural Science Foundation of China (Grant No. 21676143) and National Students' Platform for Innovation and Entrepreneurship Training Program (Grant No. 202010291006Z).


Abstract

Heterocyclic compounds are representative of a larger class of organic compounds, and worthy of attention for many reasons, chief of which is the participation of heterocyclic scaffolds in the skeleton structure of many drugs. Lipases are enzymes with catalytic versatility, and play a key role in catalyzing the reaction of carbon–carbon bond formation, allowing the production of different compounds. This article reviewed the lipase-catalyzed aldol reaction, Knoevenagel reaction, Michael reaction, Mannich reaction, etc., in the synthesis of several classes of heterocyclic compounds with important physiological and pharmacological activities, and also prospected the research focus in lipase-catalyzed chemistry transformations in the future.



Publication History

Received: 16 June 2021

Accepted: 13 August 2021

Publication Date:
15 October 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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