J Hand Microsurg 2023; 15(03): 196-202
DOI: 10.1055/s-0041-1736003
Original Article

Factors Associated with Prolonged Opioid Use after CMC Arthroplasty

1   Hand and Upper Extremity Service, Division of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
,
Jonathan Lans
1   Hand and Upper Extremity Service, Division of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
,
Jesse B. Jupiter
1   Hand and Upper Extremity Service, Division of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
,
Kyle R. Eberlin
2   Hand Surgery Service, Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
,
Rohit Garg
1   Hand and Upper Extremity Service, Division of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
,
Neal C. Chen
1   Hand and Upper Extremity Service, Division of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
› Author Affiliations

Abstract

Background Higher rates of prolonged opioid use have been reported in patients who undergo thumb carpometacarpal (CMC) arthroplasty compared with other hand procedures. Therefore, the aim of this study is to identify the risk factors associated with prolonged postoperative opioid use after CMC arthroplasty, along with reporting the number of patients who filled an opioid prescription more than 30 days postoperatively.

Materials and Methods Retrospectively, 563 opioid-naïve patients who underwent CMC arthroplasty were included. A manual chart review was performed to collect patient characteristics, and opioid use was determined based on opioid prescription by a physician. Prolonged opioid use was defined as an opioid prescription at 90 to 180 days postoperatively. A multivariable analysis was performed to identify independent factors associated with an opioid prescription at 90 to 180 days postoperatively. Patients had a median age of 60.4 years (interquartile range [IQR]: 55.5–66.9) and had a median follow-up of 7.6 years (IQR: 4.3–12.0).

Results The rates of postoperative opioid use ranged from 6.2% (53 out of 563 patients) at 30 to 59 days postoperatively to 3.9% (22 out of 563 patients) at 150 to 180 days postoperatively. In total, 17.1% (96 out of 563 patients) received a second opioid prescription more than 30 days following surgery, of which 10.8% (61 out of 563 patients) were between 90 and 180 days postoperatively. Older age, defined as a median of 63 years (IQR: 57.10–69.88) (p = 0.027, odds ratio [OR] = 1.04) and a history of psychiatric disease (p = 0.049, OR = 1.86) were independently associated with prolonged opioid use.

Conclusion A prolonged opioid use rate of roughly 11% was found in opioid-naïve patients who underwent CMC arthroplasty. In patients at risk (older patients or psychiatric history) of prolonged opioid use, careful postoperative pain management is recommended.

Supplementary Material



Publication History

Article published online:
01 October 2021

© 2021. Society of Indian Hand Surgery & Microsurgeons. All rights reserved.

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  • References

  • 1 Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and opioid-involved overdose deaths - United States, 2013-2017. MMWR Morb Mortal Wkly Rep 2018; 67 (5152) 1419-1427
  • 2 Morris BJ, Mir HR. The opioid epidemic: impact on orthopaedic surgery. J Am Acad Orthop Surg 2015; 23 (05) 267-271
  • 3 Manchikanti L, Singh A. Therapeutic opioids: a ten-year perspective on the complexities and complications of the escalating use, abuse, and nonmedical use of opioids. Pain Physician 2008; 11 (Suppl. 02) S63-S88
  • 4 Volkow ND, McLellan TA, Cotto JH, Karithanom M, Weiss SR. Characteristics of opioid prescriptions in 2009. JAMA 2011; 305 (13) 1299-1301
  • 5 Holman JE, Stoddard GJ, Higgins TF. Rates of prescription opiate use before and after injury in patients with orthopaedic trauma and the risk factors for prolonged opiate use. J Bone Joint Surg Am 2013; 95 (12) 1075-1080
  • 6 Bhashyam AR, Young J, Qudsi RA, Parisien RL, Dyer GSM. Opioid prescribing patterns of orthopedic surgery residents after open reduction internal fixation of distal radius fractures. J Hand Surg Am 2019; 44 (03) 201-207.e2
  • 7 Johnson SP, Chung KC, Zhong L. et al. Risk of prolonged opioid use among opioid-naïve patients following common hand surgery procedures. J Hand Surg Am 2016; 41 (10) 947-957.e3
  • 8 Owen GT, Burton AW, Schade CM, Passik S. Urine drug testing: current recommendations and best practices. Pain Physician 2012; 15 (Suppl. 03) ES119-ES133
  • 9 Rhon DI, Snodgrass SJ, Cleland JA, Sissel CD, Cook CE. Predictors of chronic prescription opioid use after orthopedic surgery: derivation of a clinical prediction rule. Perioper Med (Lond 2018; 7: 25
  • 10 Sabesan VJ, Chatha K, Goss L, Ghisa C, Gilot G. Can patient and fracture factors predict opioid dependence following upper extremity fractures?: a retrospective review. J Orthop Surg Res 2019; 14 (01) 316
  • 11 Helmerhorst GT, Vranceanu AM, Vrahas M, Smith M, Ring D. Risk factors for continued opioid use one to two months after surgery for musculoskeletal trauma. J Bone Joint Surg Am 2014; 96 (06) 495-499
  • 12 van Rijswijk SM, van Beek MHCT, Schoof GM, Schene AH, Steegers M, Schellekens AF. Iatrogenic opioid use disorder, chronic pain and psychiatric comorbidity: a systematic review. Gen Hosp Psychiatry 2019; 59: 37-50
  • 13 Hooten WM, St JL Sauver, McGree ME, Jacobson DJ, Warner DO. Incidence and risk factors for progression from short-term to episodic or long-term opioid prescribing: a population-based study. Mayo Clin Proc 2015; 90 (07) 850-856
  • 14 Sun EC, Darnall BD, Baker LC, Mackey S. Incidence of and risk factors for chronic opioid use among opioid-naive patients in the postoperative period. JAMA Intern Med 2016; 176 (09) 1286-1293
  • 15 Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data. Med Care 1998; 36 (01) 8-27
  • 16 van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ. A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care 47 2009; (06) 626-633
  • 17 Listed Na. Zip Code Characteristics: Mean and Median Household Income: Michigan Population Studies Center; 2010 [April 22, 2020]. Accessed on April 22, 2020 at: https://www.psc.isr.umich.edu/dis/census/Features/tract2zip/
  • 18 Brummett CM, Waljee JF, Goesling J. et al. New persistent opioid use after minor and major surgical procedures in US adults. JAMA Surg 2017; 152 (06) e170504
  • 19 Clarke H, Soneji N, Ko DT, Yun L, Wijeysundera DN. Rates and risk factors for prolonged opioid use after major surgery: population based cohort study. BMJ 2014; 348: g1251
  • 20 Brescia AA, Harrington CA, Mazurek AA. et al. Factors associated with new persistent opioid usage after lung resection. Ann Thorac Surg 2019; 107 (02) 363-368
  • 21 Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E. Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Anesth Analg 2017; 125 (05) 1733-1740
  • 22 Becker WC, Fiellin DA, Merrill JO. et al. Opioid use disorder in the United States: insurance status and treatment access. Drug Alcohol Depend 2008; 94 (1-3) 207-213
  • 23 Lagisetty PA, Healy N, Garpestad C, Jannausch M, Tipirneni R, Bohnert ASB. Access to primary care clinics for patients with chronic pain receiving opioids. JAMA Netw Open 2019; 2 (07) e196928
  • 24 Mohamadi A, Chan JJ, Lian J. et al. Risk factors and pooled rate of prolonged opioid use following trauma or surgery: a systematic review and meta-(regression) analysis. J Bone Joint Surg Am 2018; 100 (15) 1332-1340
  • 25 Wilsey BL, Fishman SM, Tsodikov A, Ogden C, Symreng I, Ernst A. Psychological comorbidities predicting prescription opioid abuse among patients in chronic pain presenting to the emergency department. Pain Med 2008; 9 (08) 1107-1117
  • 26 Wise KL, McCreary DL, Parikh HR. et al. Factors associated with a second opioid prescription fill in total knee arthroplasty. J Arthroplasty 2020; 35 (6S) S163-S167
  • 27 Orfield NJ, Gaddis A, Russell KB, Hartman DW, Apel PJ, Mierisch C. New long-term opioid prescription-filling behavior arising in the 15 months after orthopaedic surgery. J Bone Joint Surg Am 2020; 102 (04) 332-339
  • 28 Speed TJ, Parekh V, Coe W, Antoine D. Comorbid chronic pain and opioid use disorder: literature review and potential treatment innovations. Int Rev Psychiatry 2018; 30 (05) 136-146
  • 29 Chou R, Gordon DB, de Leon-Casasola OA. et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016; 17 (02) 131-157
  • 30 Cheung CW, Ching Wong SS, Qiu Q, Wang X. Oral oxycodone for acute postoperative pain: a review of clinical trials. Pain Physician 2017; 20 (2S) SE33-SE52
  • 31 Barnett ML, Olenski AR, Jena AB. Opioid-prescribing patterns of emergency physicians and risk of long-term use. N Engl J Med 2017; 376 (07) 663-673
  • 32 Vadivelu N, Mitra S, Hines R, Elia M, Rosenquist RW. Acute pain in undergraduate medical education: an unfinished chapter!. Pain Pract 2012; 12 (08) 663-671
  • 33 Vadivelu N, Kombo N, Hines RL. The urgent need for pain management training. Acad Med 2009; 84 (04) 408
  • 34 Chapman NH, Lazar SP, Fry M, Lassere MN, Chong BH. Clinicians adopting evidence based guidelines: a case study with thromboprophylaxis. BMC Health Serv Res 2011; 11: 240
  • 35 Traynor K. Maine enacts statewide limits on opioid prescribing. Am J Health Syst Pharm 2016; 73 (12) 854-856
  • 36 Ovadia SA, Garcia Jr O, Thaller SR. Changes in opioid prescribing patterns: a survey of the Florida Society of Plastic Surgeons. Ann Plast Surg 2020; 85 (06) e54-e58