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CC BY 4.0 · Surg J (N Y) 2021; 07(04): e314-e318
DOI: 10.1055/s-0041-1735899
Research Article

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain

Mohamad Aryafar
1   Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
,
Mahnaz Narimani Zamanabadi
1   Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
,
Kourosh Farazmehr
1   Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
,
Giti Dehghanmanshadi
1   Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
,
Sepideh Davoodinejad
2   Student of Research Committee, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
,
Farshid Gholami
1   Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
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Abstract

This study was performed to determine the comparative efficacy of paracetamol alone versus paracetamol plus ondansetron on acute postoperative pain after abdominal surgeries in Azad University hospitals in 2017 and 2019. In this randomized clinical trial, 62 consecutive patients under abdominal surgeries, were randomly divided into two groups, group 1 patient who received paracetamol alone 1 gram and group 2 patient who received paracetamol 1 gram plus 4 mg ondansetron and the pain severities were determined and compared between groups at recovery and after 4 and 24 hours. The results of this study revealed that there were no statistically significant differences between two groups for the postoperative pain severity and analgesic use (p> 0.05). It may be concluded that addition of ondansetron to paracetamol would not result in further postoperative pain reduction and additive use of this drug is not recommended.

Keywords

postoperative pain - ondansetron - paracetamol - abdominal surgeries - analgesic use - severity

Ethical Approval and Consent to Participate

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.


This study was approved by the Research Ethics Committee, Board at the Azad University of Medical Sciences. (IR.IAU.TMU.REC.1395.260) on November 23, 2018 and was in accordance with the Helsinki principles.


Authors' Contribution

M.A. and F.G. conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. M.N. and K.F. designed the data collection instruments, collected data, carried out the initial analyses, and reviewed and revised the manuscript. G.D. and S.D. coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content.


Supplementary Material



Publikationsverlauf

Eingereicht: 03. September 2019

Angenommen: 26. Juli 2021

Artikel online veröffentlicht:
15. Dezember 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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