Short-Term Outcomes in Neonates and Preterm Infants with SARS-CoV-2 Infection Acquired Postpartum

Abstract

Objective There are limited data regarding the hospital and postdischarge course of novel coronavirus disease 2019 (COVID-19) in newborns. This study aimed to present the data of such cases in newborns.

Methods We retrospectively evaluated the predischarge and postdischarge records of newborns followed-up in the neonatal intensive care unit between June 2, 2020, and April 30, 2021 and who had positive polymerase chain reaction (PCR) test for COVID-19.

Results Eleven newborns had positive PCR tests for COVID-19 during the study period. The prenatal COVID-19 PCR test of the mothers of the newborns was negative. The cases with a postnatal age of 10 to 60 days according to chronological age were hospitalized due to positive COVID-19 PCR test. Either or both the parents of these cases were severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) PCR positive on nasopharyngeal swab obtained simultaneously. All breast milk samples were negative for COVID-19 virus. The mean D-dimer value of the cases was 3,430 µg FEU/L at the time of hospitalization and 307 µg FEU/L after discharge. None of the cases were given any specific antiviral treatment. The cases were discharged with full recovery. No rehospitalizations or deaths occurred during the 3-month follow-up after discharge.

Conclusion In most COVID-19 newborns, the disease was transmitted by infected parents, and the course of the infection was either asymptomatic or associated with only mild symptoms. No complications or deaths were observed during the 3-month follow-up after discharge.

Keywords

newborn - COVID-19 - follow-up - SARS-COV-2

Publikationsverlauf

Eingereicht: 18. Januar 2021

Angenommen: 16. August 2021

Artikel online veröffentlicht:
20. Oktober 2021

• References

• 1 Abu-Rustum RS, Akolekar R, Sotiriadis A. et al. ISUOG Consensus Statement on organization of routine and specialist obstetric ultrasound services in context of COVID-19. Ultrasound Obstet Gynecol 2020; 55 (06) 863-870
• 2 Di Mascio D, Sen C, Saccone G. et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med 2020; 49 (01) 111-115
• 3 Guan W-J, Liang W-H, Zhao Y. et al; China Medical Treatment Expert Group for COVID-19. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J 2020; 55 (05) 2000547
• 4 Zamaniyan M, Ebadi A, Mir SA, Rahmani Z, Haghshenas M, Azizi S. Iatrogenic preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission: a case report. 2020; DOI: 10.22541/au.158524968.82178769.
• 5 Salvatore CM, Han J-Y, Acker KP. et al. Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study. Lancet Child Adolesc Health 2020; 4 (10) 721-727
• 6 Molloy EJ, Lavizzari A, Klingenberg C. et al. International Neonatal COVID-19 Consortium. Neonates in the COVID-19 pandemic. Pediatr Res 2021; 89 (05) 1038-1040
• 7 Lauer SA, Grantz KH, Bi Q. et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med 2020; 172 (09) 577-582
• 8 Li Q, Zheng X-S, Shen X-R. et al. Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19. Emerg Microbes Infect 2020; 9 (01) 2571-2577
• 9 Dong Y, Mo X, Hu Y. et al. Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145 (06) e20200702
• 10 Erdeve Ö, Çetinkaya M, Baş AY. et al. The Turkish Neonatal Society proposal for the management of COVID-19 in the neonatal intensive care unit. Turk Pediatri Ars 2020; 55 (02) 86-92
• 11 Kallem VR, Sharma D. COVID 19 in neonates. J Matern Fetal Neonatal Med 2020; 18: 1-9
• 12 Kotlyar AM, Grechukhina O, Chen A. et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol 2021; 224 (01) 35-53.e3
• 13 Wang L, Shi Y, Xiao T. et al. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (first edition). Ann Transl Med 2020; 8 (03) 47
• 14 Correia CR, Marçal M, Vieira F. et al. Congenital SARS-CoV-2 infection in a neonate with severe acute respiratory syndrome. Pediatr Infect Dis J 2020; 39 (12) e439-e443
• 15 Interim clinical guidance for management of patients with confirmed coronavirus disease (COVID-19). Accessed January 11, 2021 at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html
• 16 Kanburoglu MK, Tayman C, Oncel MY. et al. A multicentered study on epidemiologic and clinical characteristics of 37 neonates with community-acquired COVID-19. Pediatr Infect Dis J 2020; 39 (10) e297-e302
• 17 Trevisanuto D, Cavallin F, Cavicchiolo ME, Borellini M, Calgaro S, Baraldi E. Coronavirus infection in neonates: a systematic review. Arch Dis Child Fetal Neonatal Ed 2021; 106 (03) 330-335
• 18 Mark EG, Golden WC, Gilmore MM. et al. Community-onset severe acute respiratory syndrome coronavirus 2 infection in young infants: a systematic review. J Pediatr 2021; 228: 94-100.e3
• 19 Jiménez S, Miró Ò, Llorens P. et al; Spanish Investigators on Emergency Situations TeAm (SIESTA) network. Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S8. Eur J Emerg Med 2021; 28 (03) 218-226
• 20 El Rhalete A, Rhazi I, Bensaid A. et al. Cardiovascular injuries during COVID-19 infection: A PROCESS-compliant case series from the Eastern Morocco. Ann Med Surg (Lond) 2021; 65: 102309
• 21 Li J, Yang L, Zeng Q. et al. Determinants of mortality of patients with COVID-19 in Wuhan, China: a case-control study. Ann Palliat Med 2021; 10 (04) 3937-3950
• 22 Monagle P, Barnes C, Ignjatovic V. et al. Developmental haemostasis. Impact for clinical haemostasis laboratories. Thromb Haemost 2006; 95 (02) 362-372
• 23 Hudson IR, Gibson BE, Brownlie J, Holland BM, Turner TL, Webber RG. Increased concentrations of D-dimers in newborn infants. Arch Dis Child 1990; 65 (4 spec no): 383-384
• 24 Yildiz H, Yarci E, Bozdemir SE. et al. COVID-19-associated cerebral white matter injury in a newborn infant with afebrile seizure. Pediatr Infect Dis J 2021; 40 (07) e268-e269
• 25 Kloc M, Ghobrial RM, Kuchar E, Lewicki S, Kubiak JZ. Development of child immunity in the context of COVID-19 pandemic. Clin Immunol 2020; 217: 108510
• 26 Walker KF, O'Donoghue K, Grace N. et al. Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG 2020; 127 (11) 1324-1336
• 27 Xue RH. Re: Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG 2020; 127 (13) 1713
• 28 Caso F, Costa L, Del Puente A. et al. Clinical effects of mud-bath therapy and oral glucosamine sulfate after 6 months of discontinuation in patients with knee osteoarthritis: results from a randomised, controlled, crossover study. Clin Exp Rheumatol 2017; 35 (01) 169