CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2021; 42(04): 356-359
DOI: 10.1055/s-0041-1735392
Trainees’ Corner

Molecular Classification of Diffuse Large B-Cell Lymphoma

Annie Kanchan Baa
1   Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
1   Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
› Author Affiliations


Diffuse large B cell lymphoma (DLBCL) is the commonest type of non-Hodgkin lymphoma (NHL) in adults, accounting for around 30 to 35% of all NHL cases.[1] [2] With current standards of care, up to 50 to 70% of these patients can achieve a lasting remission.[1] Of the remaining patients, the relapsed/refractory cases, cure is only possible in 10%, even with further lines of therapy or stem cell transplant.[1] This heterogeneity in DLBCL’s clinical behavior reflects the underlying molecular heterogeneity of the disease. Thankfully, we are now able to understand this heterogeneity a little better and subtype DLBCL cases based on immunohistochemistry (IHC) and molecular markers, enabling us to have deeper prognostic insights and helping us to make therapeutic decisions. The various classification systems in use for DLBCL include the “cell-of-origin” (COO) classification, the comprehensive consensus clustering classification, double-hit/triple-hit lymphomas (DHL/THL), double-expressor lymphomas (DEL), and the modern classification.

Supplementary Material

Publication History

Article published online:
25 November 2021

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