Abstract
Anastomotic leak in patients with rectal cancer has the potential to cause worse oncologic
outcomes in addition to major morbidity and mortality risk of this dreaded complication.
Anatomic location of the rectal cancer determines the ability to perform a restorative
operation and the height of the anastomosis in relation to the anal canal. Clinical
staging dictates the need for neoadjuvant treatment (such as chemotherapy and radiation)
which may also contribute to anastomotic leak risk. In addition to oncologic outcomes,
anastomotic leak can impact bowel function, the need for permanent stoma, and long-term
quality of life. This study will discuss special considerations for anastomotic leak
prevention and clinical implications of this complication in patients with rectal
cancer.
Keywords
rectal cancer - anastomotic leak - function - oncologic outcome
