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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2021; 31(03): 551-559
DOI: 10.1055/s-0041-1734411
Original Article

Imaging Spectrum of Lobular Carcinoma In Situ and Correlation with Pathology Findings

Pradipta C Hande
1   Department of Radiology and Imaging, Breach Candy Hospital Trust, Bhulabhai Desai Road, Mumbai, Maharashtra, India
,
Sarabjeet Kaur Arneja
2   Department of Surgical Pathology and Cytology, Breach Candy Hospital Trust, Bhulabhai Desai Road, Mumbai, Maharashtra, India
,
Sabita S Desai
3   Department of Radiology, Breach Candy Hospital Trust, Bhulabhai Desai Road, Mumbai, Maharashtra, India
› Author Affiliations Financial Support and Sponsorship Nil.
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Abstract

Background Lobular carcinoma in situ (LCIS) is a noninvasive neoplasm that is known to have an increased relative risk for developing subsequent invasive breast carcinoma. Pure LCIS is usually an incidental finding on histopathological examination (HPE) of tissue samples. However, in the recent years, there has been an increasing trend seen in the diagnosis of LCIS.

Purpose This article aims to bring out the spectrum of appearances on breast imaging in confirmed cases of pure LCIS on HPE and immunohistochemical.

Materials and Methods Cases that were confirmed as pure LCIS on HPE from core or excision biopsy were retrospectively analyzed for abnormalities on breast imaging. Digital breast tomosynthesis mammography was performed with high-resolution ultrasound with elastography for all cases. Magnetic resonance imaging (MRI) was performed in cases wherever indicated, with dynamic postcontrast imaging after injecting intravenous gadolinium.

Conclusion LCIS is recognized as an intermediate risk factor for the development of breast cancer. Pure LCIS has varied histology and imaging patterns on mammography, high-resolution ultrasound, and MRI. It is important to recognize the imaging appearances of these lesions to enable the radiologist to detect LCIS early for proper management.

Keywords

architectural distortion - digital breast tomosynthesis - hook-wire localization - immunohistochemistry - lobular carcinoma in situ - microcalcifications


Publication History

Article published online:
23 August 2021

© 2021. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Wen HY, Brogi E. Lobular carcinoma in situ. Surg Pathol Clin 2018; 11 (01) 123-145
    CrossrefPubMedGoogle Scholar
  • 2 Schwartz T, Cyr A, Margenthaler J. Screening breast magnetic resonance imaging in women with atypia or lobular carcinoma in situ. J Surg Res 2015; 193 (02) 519-522
    CrossrefPubMedGoogle Scholar
  • 3 Chu AJ, Cho N, Park IA, Cho SW. Features of pure lobular carcinoma in situ on magnetic resonance imaging associated with immediate re-excision after lumpectomy. J Breast Cancer 2016; 19 (02) 199-205
    CrossrefPubMedGoogle Scholar
  • 4 Arpino G, Laucirica R, Elledge RM. Premalignant and in situ breast disease: biology and clinical implications. Ann Intern Med 2005; 143 (06) 446-457
    CrossrefPubMedGoogle Scholar
  • 5 Sung JS, Malak SF, Bajaj P, Alis R, Dershaw DD, Morris EA. Screening breast MR imaging in women with a history of lobular carcinoma in situ. Radiology 2011; 261 (02) 414-420
    CrossrefPubMedGoogle Scholar
  • 6 D’Orsi C, Sickles EA, Mendelson EB, Morris EA. Breast Imaging Reporting and Data System: ACR BI-RADS Breast Imaging Atlas. 5th edition. Reston, VA: American College of Radiology 2013
  • 7 Chaudhary S, Lawrence L, McGinty G, Kostroff K, Bhuiya T. Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. Mod Pathol 2013; 26 (06) 762-771
    CrossrefPubMedGoogle Scholar
  • 8 Graziano L, Bitencourt AGV, Guatelli CS. et al. Lobular carcinoma in situ with atypical mass presentation: a case report. Rev Bras Ginecol Obstet 2016; 38 (02) 112-116
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Jorns J, Sabel MS, Pang JC. Lobular neoplasia: morphology and management. Arch Pathol Lab Med 2014; 138 (10) 1344-1349
    CrossrefPubMedGoogle Scholar
  • 10 Zhao C, Desouki MM, Florea A, Mohammed K, Li X, Dabbs D. Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. Am J Clin Pathol 2012; 138 (01) 72-78
    CrossrefPubMedGoogle Scholar
  • 11 Murray MP, Luedtke C, Liberman L, Nehhozina T, Akram M, Brogi E. Classic lobular carcinoma in situ and atypical lobular hyperplasia at percutaneous breast core biopsy: outcomes of prospective excision. Cancer 2013; 119 (05) 1073-1079
    CrossrefPubMedGoogle Scholar
  • 12 Eisenberg RE, Hoda SA. Lobular carcinoma in situ with collagenous spherulosis: clinicopathologic characteristics of 38 cases. Breast J 2014; 20 (04) 440-441
    CrossrefPubMedGoogle Scholar
  • 13 Tan H, Zhang H, Lei Z, Fu F, Wang M. Radiological and clinical findings in sclerosing adenosis of the breast. Medicine (Baltimore 2019; 98 (39) e17061
    CrossrefPubMedGoogle Scholar
  • 14 Stein LF, Zisman G, Rapelyea JA, Schwartz AM, Abell B, Brem RF. Lobular carcinoma in situ of the breast presenting as a mass. AJR Am J Roentgenol 2005; 184 (06) 1799-1801
    CrossrefPubMedGoogle Scholar
  • 15 Christiano JG, Duncan LD, Bell JL. Lobular carcinoma in situ of the breast presenting as a discrete mass. Am Surg 2012; 78 (01) E38-E40
    CrossrefPubMedGoogle Scholar
  • 16 Maxwell AJ, Clements K, Dodwell DJ. et al. Sloane Project Steering Group. The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: findings from the Sloane Project. Breast 2016; 27: 109-115
    CrossrefPubMedGoogle Scholar
  • 17 Flanagan MR, Rendi MH, Calhoun KE, Anderson BO, Javid SH. Pleomorphic lobular carcinoma in situ: Radiologic-pathologic features and clinical management. Ann Surg Oncol 2015; 22 (13) 4263-4269
    CrossrefPubMedGoogle Scholar
  • 18 Hwang ES, Nyante SJ, Yi Chen Y. et al. Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma. Cancer 2004; 100 (12) 2562-2572
    CrossrefPubMedGoogle Scholar
  • 19 Begg CB, Ostrovnaya I, Carniello JV. et al. Clonal relationships between lobular carcinoma in situ and other breast malignancies. Breast Cancer Res 2016; 18 (01) 66
    CrossrefPubMedGoogle Scholar