V-195 Establishment of primary pleural mesothelium with 3D organotypic co-culture

Hintergrund

Pleural mesothelial cells (PMCs) lead the pleural immune response and serve as progenitor cells after pleural or lung damage. They therefore play a key role in pleural diseases such as bacterial infections, malignant pleural effusion, pleural carcinosis or pleural mesothelioma. All these diseases prove a significant healthcare burden, however, its scientific consideration is quite low. The aim of the present study was to develop a three-dimensional (3D) in vitro organotypic model for investigation of pathological conditions of the pleural mesothelium. 3D organotypic models are a promising approach to gain an in vivo like understanding of molecular disease development. While these models are well established for a variety of organs, such as lung, colon, intestine, liver, pancreas, esophagus, prostate, or omentum majus, a 3D organoid model of the pleura is still missing.

Publication History

Article published online:
06 September 2021