Zentralbl Chir 2021; 146(S 01): S71
DOI: 10.1055/s-0041-1733417
Abstracts

V-183 Nivolumab with chemotherapy in pleural mesothelioma after surgery – the NICITA trial

L Klotz
1   Thoraxklinik am Universitätsklinikum Heidelberg, Thoraxchirurgie, Heidelberg, Deutschland
,
M Thomas
2   Thoraxklinik Heidelberg, Heidelberg, Deutschland
,
F Eichhorn
2   Thoraxklinik Heidelberg, Heidelberg, Deutschland
,
S Bölukbas
3   Klinikum Essen Mitte, Essen, Deutschland
,
M Ried
4   Universitätsklinikum Regensburg, Regensburg, Deutschland
,
S Welter
5   Lungenklinik Hemer, Hemer, Deutschland
,
S Eggeling
6   Vivantes Klinikum Neukölln, Berlin, Deutschland
,
S Meierling
7   Asklepios Klinik Harburg, Hamburg, Deutschland
,
T Hoppert
8   Klinikum Bremen-Ost, Bremen, Deutschland
,
C Kugler
9   Lungenklinik Großhansdorf, Großhansdorf, Deutschland
,
G Preissler
10   Klinik Schillerhöhe, Stuttgart, Deutschland
,
R Hatz
11   Asklepios Lungenfachklinik Gauting, Gauting, Deutschland
,
E Stoelben
12   Lungenklinik Köln Merheim, Köln, Deutschland
,
B Passlick
13   Universitätsklinikum Freiburg, Freiburg, Deutschland
,
M Eichhorn
2   Thoraxklinik Heidelberg, Heidelberg, Deutschland
,
R Shah
2   Thoraxklinik Heidelberg, Heidelberg, Deutschland
› Author Affiliations
› Further Information
Also available at
 

Hintergrund

Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the pleura associated with exposure to asbestos. Currently, there is no approved standard treatment of early-stage MPM. If possible, a multimodal treatment by cytoreductive surgery with or without hyperthermic intrathoracic chemoperfusion (HITOC) in combination with inductive or additive chemotherapy is performed. Considering the immunogenic effects of chemotherapy on the tumor microenvironment, synergistic effects might be potentiated in combination with immune checkpoint inhibitor therapy. Moreover, interactions between immune infiltrates and mesothelioma cells have been described to have a beneficial impact for immunotherapy in MPM.



Publication History

Article published online:
06 September 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany