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DOI: 10.1055/s-0041-1731969
Incidence and Patterns of Liver Cancers in Sri Lanka from 2001 to 2010: Analysis of National Cancer Registry Data
Funding None.
Abstract
Objectives Varying trends in the incidence of liver cancer have been observed in many Asian countries. We conducted this study to examine trends in liver cancer incidence and histological patterns in Sri Lanka.
Materials and Methods All newly diagnosed patients with liver cancer included in Sri Lanka National Cancer Registry during 2001 to 2010 were analyzed.
Statistical Analysis Joinpoint regression analysis was performed. A p-value of less than 0.05 was considered statistically significant.
Results Overall, 1,482 (male:female = 2.7:1; mean age = 57.5 years) liver cancers were analyzed. Majority were hepatocellular carcinomas (n = 1,169; 78.9%), followed by intrahepatic cholangiocarcinomas (n = 100; 6.75%). Highest incidence of liver cancer was observed in 70–74-year age group (5.1/100,000). Overall, the World Health Organization age-standardized rate (ASR) has increased during 2001 to 2004, from 0.6/100,000 (95% confidence interval [CI] = 0.48–0.72) to 1.0/100,000 (95% CI = 0.85–1.15), with an estimated annual percentage change (EAPC) of 17.8 (95% CI = 5.0–46.2); p > 0.05. From 2004 to 2010, a gradual decline in the incidence was observed. ASR in 2010 was 0.96 (95% CI = 0.81–1.1), with an EAPC of –0.9 (95% CI = –6.7 to 5.4); p > 0.05. Similar patterns of incidence change were observed in both genders.
Conclusions Overall, the incidence of liver cancer appears to be steadily declining in Sri Lanka. Similar patterns of incidence change were observed in both genders. The actual decline is likely to be greater as it is likely that diagnostic scrutiny and reporting would have improved during the study period.
Ethical Approval Statement
Ethical approval for th is study was obtained from the ethical review committee of Faculty of Medicine, University of Colombo.
Authors' Contributions
UJ, VU, and AF analyzed the data and wrote the first version of the manuscript. AF, SS, and DNS provided the data, advised on analysis, and provided comments on the manuscript. UJ, VU, SS, and DNS conceived the idea, supervised the data analysis, and wrote the final version of the manuscript. All authors read and approved the final manuscript.
Declaration
The abstract of this study was presented at the Asian-Pacific Digestive Week 2019 held in Kolkata, India.[22]
List of Abbreviations
WHO: World Health Organization
EAPC: Estimated annual percentage change
CI: Confidence interval
ASR: Age-standardized rate
HCC: Hepatocellular carcinoma
ICC: Intrahepatic cholangiocarcinoma
HBV: Hepatitis B Virus
HCV: Hepatitis C Virus
Publication History
Article published online:
25 April 2022
© 2022. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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