Thromb Haemost 2022; 122(05): 666-678
DOI: 10.1055/s-0041-1731717
Review Article

Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and Diseases

Serge Mbiandjeu
1   Department of Molecular Medicine, University of Pavia, Pavia, Italy
,
Alessandra Balduini
1   Department of Molecular Medicine, University of Pavia, Pavia, Italy
,
Alessandro Malara
1   Department of Molecular Medicine, University of Pavia, Pavia, Italy
› Author Affiliations
Funding This study was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC IG 2016 18700, AIRC; Milano, Italy) and U.S. National Institutes of Health (R01-HL134829) to A.B.

Abstract

Thrombopoiesis governs the formation of blood platelets in bone marrow by converting megakaryocytes into long, branched proplatelets on which individual platelets are assembled. The megakaryocyte cytoskeleton responds to multiple microenvironmental cues, including chemical and mechanical stimuli, sustaining the platelet shedding. During the megakaryocyte's life cycle, cytoskeletal networks organize cell shape and content, connect them physically and biochemically to the bone marrow vascular niche, and enable the release of platelets into the bloodstream. While the basic building blocks of the cytoskeleton have been studied extensively, new sets of cytoskeleton regulators have emerged as critical components of the dynamic protein network that supports platelet production. Understanding how the interaction of individual molecules of the cytoskeleton governs megakaryocyte behavior is essential to improve knowledge of platelet biogenesis and develop new therapeutic strategies for inherited thrombocytopenias caused by alterations in the cytoskeletal genes.



Publication History

Received: 23 September 2020

Accepted: 21 May 2021

Article published online:
04 July 2021

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