The Mechanism of Interleukin-35 in Chronic Hepatitis B

Abstract

Interleukin-35 (IL-35) is a newly identified inhibitory cytokine. It has recently been found to play an extremely important role in chronic hepatitis B disease, which makes it likely to be a target for new therapies for hepatitis B malady. IL-35 modulates a variety of immune mechanisms to cause persistent viral infections, such as affecting the ratio of helper T cells, reducing the activity of cytotoxic T cells, hindering the antigen presentation capacity for dendritic cells, and increasing the transcription level of hepatitis B virus. On the other hand, IL-35 can control the inflammation caused by hepatitis B liver injury. Therefore, to seek a breakthrough in curing hepatitis B disease, the contradictory part of IL-35 in the occurrence and development of this sickness is worthy of further discussion and research. This article will systematically review the biological effects of IL-35 and the specific mechanisms affecting the disease.

Keywords

interleukin-35 - chronic hepatitis B - JAK/STAT - Treg/Th17 - PD-1

Authors' Contribution

Y.T. contributed to manuscript writing; T.M., S.J., and M.W. conducted literature retrieval; and L.Q. and L.Y. revised the manuscript.

Publikationsverlauf

Artikel online veröffentlicht:
07. Juli 2021

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