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J Pediatr Infect Dis 2021; 16(06): 247-254
DOI: 10.1055/s-0041-1731643
Original Article

Associations of Antimicrobial-Resistant Gram-Negative Bloodstream Infections with Outcomes among Hospitalized Pediatric Patients in the United States

Alicen Burns Spaulding 
1   Children's Minnesota Research Institute, Minneapolis, Minnesota, United States
,
David Watson 
1   Children's Minnesota Research Institute, Minneapolis, Minnesota, United States
,
Jill Dreyfus
2   Premier, Inc., United States
,
Phillip Heaton
1   Children's Minnesota Research Institute, Minneapolis, Minnesota, United States
,
Christina Koutsari 
3   Antimicrobial Stewardship Program, Children's Minnesota, Minneapolis, Minnesota, United States
,
Anupam B. Kharbanda
4   Pediatric Emergency Medicine, Chief of Critical Care Services, Children's Minnesota, Minneapolis, Minnesota, United States
› Author Affiliations Funding This work was supported in part by the Internal Research Grant Program at Children's Minnesota.
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Abstract

Objective The aim of this study was to assess the impact of pediatric antimicrobial-resistant gram-negative bloodstream infections (GNBSIs).

Methods A retrospective cohort study (2009–2016) was conducted using the Premier Healthcare Database among pediatric admissions with GNBSIs at hospitals reporting microbiology data. Infections for neonates and nonneonates were classified as multidrug resistance (MDR), resistant to one or two antibiotic drug classes (1–2DR), or susceptible.

Results Among 1,276 GNBSIs, 266 (20.8%) infections were 1–2DR and 23 (1.8%) MDR. Compared with susceptible GNBSIs, MDR nonneonates had higher mortality and higher costs, whereas 1–2DR neonates had longer stays and higher costs.

Conclusions Antimicrobial-resistant GNBSIs were associated with worse outcomes among pediatric hospitalized patients.

Keywords

antimicrobial resistance - bloodstream infections - pediatric

Supplementary Material



Publication History

Received: 01 September 2020

Accepted: 23 April 2021

Article published online:
28 July 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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