J Pediatr Infect Dis 2021; 16(05): 194-199
DOI: 10.1055/s-0041-1731409
Original Article

Taxonomy of Pathogen Codetection in Pediatric Case Fatalities with Adenoviral Respiratory Infection

Emily K. Ninmer
1  Department of Pediatrics, Division of Pediatric Critical Care, University of Virginia School of Medicine, Charlottesville, Virginia, United States
,
Claire Stewart
2  Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States
,
3  Division of Critical Care Medicine, Children's National Hospital, Washington, United States
,
4  Division of Pediatric Critical Care, Inova Children's Hospital, Falls Church, Virginia, United States
,
Natalia Martinez-Schlurman
5  Division of Pediatric Critical Care, University of Florida School of Medicine, Gainesville, Florida, United States
,
Robert P. Kavanagh
6  Division of Pediatric Critical Care, Penn State College of Medicine, Hershey, Pennsylvania, United States
,
7  Division of Pediatric Critical Care, University of California at Davis School of Medicine, Sacramento, California, United States
,
Michael C. McCrory
8  Division of Pediatric Critical Care, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
,
9  Division of Pediatric Critical Care, Yale University School of Medicine, New Haven, Connecticut, United States
,
Anjali V. Subbaswamy
10  Division of Pediatric Critical Care, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States
,
11  Division of Pediatric Critical Care, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States
,
Mary Lynn Sheram
12  Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia, United States
,
12  Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia, United States
,
1  Department of Pediatrics, Division of Pediatric Critical Care, University of Virginia School of Medicine, Charlottesville, Virginia, United States
› Author Affiliations
Funding None.

Abstract

Objective The aim of this study was to determine the prevalence and taxonomy of pathogen codetection in pediatric case fatalities associated with adenoviral respiratory infection.

Methods This retrospective case series included 107 pediatric case fatalities associated with adenoviral respiratory infection.

Results We observed a high rate of pathogen codetection with broad diversity from both respiratory and nonrespiratory sources. We noted differences in codetection characteristics based on immune status; most notably that immunocompromised cases were more likely to have bacteremia and adenoviremia.

Conclusions In pediatric case fatalities associated with adenoviral respiratory infection, we observed a high degree of pathogen codetection.

Note

Study coordination and all data analyses were performed at the University of Virginia.




Publication History

Received: 05 December 2020

Accepted: 17 April 2021

Publication Date:
16 July 2021 (online)

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