J Pediatr Infect Dis 2021; 16(05): 242-246
DOI: 10.1055/s-0041-1731344
Rapid Communication

Cumulative Antimicrobial Susceptibility Data of Pseudomonas Aeruginosa Isolates from Cystic Fibrosis Patients: 4-Year Experience

Ebru Fidan
1  Medical Microbiology Department, Faculty of Medicine, Marmara University, Istanbul, Turkey
,
Gamze Alci
1  Medical Microbiology Department, Faculty of Medicine, Marmara University, Istanbul, Turkey
,
Seda Sevilay Koldaş
1  Medical Microbiology Department, Faculty of Medicine, Marmara University, Istanbul, Turkey
,
Bülent Karadag
2  Division of Pediatric Pulmonology, Marmara University Hospital, Istanbul, Turkey
,
Yasemin Gökdemir
2  Division of Pediatric Pulmonology, Marmara University Hospital, Istanbul, Turkey
,
Ela Erdem Eralp
2  Division of Pediatric Pulmonology, Marmara University Hospital, Istanbul, Turkey
,
Aysegül Karahasan Yagcı
1  Medical Microbiology Department, Faculty of Medicine, Marmara University, Istanbul, Turkey
› Author Affiliations
Funding None.

Abstract

ObjectivePseudomonas aeruginosa is the most important cause of lung infection among cystic fibrosis (CF) patients, and to reduce the severity of the infection, facility-specific cumulative antibiograms could help clinicians in empirical treatment.

Methods Respiratory samples of CF patients between January 2015 and December 2018 were scanned through Laboratory Operating System retrospectively. Demographical data of patients, culture results, and antibiotic susceptibilities are recorded using Microsoft Excel 2010. Cumulative antibiogram data were obtained according to the CLSI M39A4 document.

Results The number of registered patients increased in 4 years from 154 to 253. The mean age of patients varied from 9 to 11.7 (range, 2–42). The ratio of patients with a positive culture for P. aeruginosa increased from 32 to 40%, and the mean patients' age decreased from 16.6 to 11.1 (p <0.05). A total number of 4,146 respiratory samples were analyzed. Sputum samples consisted of 42.5% (n: 1,767) of the samples with a 58.4% isolation rate of P. aeruginosa (n: 1,034). A notable increase of resistance was seen almost all antimicrobials tested by years. The ratio of multidrug-resistant (MDR) P. aeruginosa was 4.1, 10.2, 4.5, and 8.6% in 2015, 2016, 2017, and 2018.

Conclusion Antimicrobial resistance is a challenging problem in CF patients, and surveillance should be done regularly.



Publication History

Received: 21 September 2020

Accepted: 16 May 2021

Publication Date:
07 July 2021 (online)

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