Abstract
Background Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver
transplantation in infants. With the realization that NH results from the fetal complement-mediated
liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for
the treatment.
Case Presentation We present two cases of NH from the same family to illustrate the role of antenatal
treatment with IVIG in alleviation and possible prevention of this serious morbidity.
Conclusion A prenatal treatment and early postnatal administration of IVIG are effective ways
to manage NH that help to reduce the severity of the symptoms, prevent liver failure,
and avoid the need for liver transplantation.
Keywords neonatal hemochromatosis - intravenous immunoglobulin - prenatal treatment - case
report
