CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2021; 57(03): 118-121
DOI: 10.1055/s-0041-1731146
Brief Report

Novel Approaches in the Management of Type 2 Diabetes and Associated Vascular Complications

K. V. S. Hari Kumar
1   Department of Endocrinology, Command Hospital, Panchkula, Haryana, India
› Author Affiliations

Abstract

Diabetes mellitus (DM) is growing in pandemic proportion and affects the affluent and developing nations equally. India has the dubious distinction of being known as the diabetes capital of the world. Epidemiological studies have shown that DM is under diagnosed and inadequately treated in our country. Insulin resistance and β-cell dysfunction are the two key pathophysiological determinants of the DM. The disease has metamorphosed during the last couple of decades with a significant change in the clinical presentation. Simultaneously, the therapeutic options for the management of DM have also increased in the last decade. This article highlights the research conducted by us over the last decade in the areas of pathogenesis, management, and complications of DM.



Publication History

Article published online:
09 June 2021

© 2021. National Academy of Medical Sciences (India). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Hari Kumar KVS. The good, the bad, and the ugly facets of insulin resistance. Med J Armed Forces India 2020; 76 (01) 4-7
  • 2 Hari KVS Kumar, Misra A. Endocrine and diabetes research from SAARC (South Asian Association for Regional Cooperation) countries. Indian J Endocrinol Metab 2013; 17 (05) 950-951
  • 3 Kalra S, Hari Kumar KVS. Seven sinful sisters: seven smart solutions to stop diabetes. J Pak Med Assoc 2018; 68 (11) 1727-1728
  • 4 Hari Kumar KVS, Gupta AK, Kumar A. Attitude of health care professionals about the diabetes from India. J Soc Health Diabetes 2014; 2: 92-95
  • 5 Hari Kumar KVS, Kumar S, Anish SR, Pillarisetti S. Assessment of diabetes empowerment amongst patients from India. J Soc Health Diabetes 2014; 2: 77-81
  • 6 Hari KVS Kumar, Manrai M, Sood AK, Sharma R. A clinical study of insulin resistance in patients with chronic pancreatitis. Diabetes Metab Syndr 2017; 11 (Suppl. 01) S283-S286
  • 7 Kumar HK, Yadav RK, Prajapati J, Reddy CV, Raghunath M, Modi KD. Association between thyroid hormones, insulin resistance, and metabolic syndrome. Saudi Med J 2009; 30 (07) 907-911
  • 8 Hari KVS Kumar, Patnaik SK. A long term follow-up study from India assessing the risk of diabetes mellitus in service population. Diabetes Metab Syndr 2018; 12 (02) 87-90
  • 9 Hari KVS Kumar, Priya S, Shaikh A, Prusty P. Diabetes in young–unusual case presentation. J Pediatr Endocrinol Metab 2011; 24 (7-8) 581-583
  • 10 Kotwal N, Upreti V, Hari Kumar KVS, Nachankar A. Etiopathological differentiation of diabetes mellitus in lean, young adults. Diabetes Metab Syndr 2017; 11 (Suppl. 02) S771-S774
  • 11 Hari KVS Kumar, Sharma R, Manrai M, Sood AK. Visceral adipose tissue as a risk factor for diabetes mellitus in patients with chronic pancreatitis: a cross-sectional, observational study. Diabetes Ther 2017; 8 (05) 1057-1064
  • 12 Modi KD, Ahmed MI, Chandwani R, Hari Kumar KVS. Prevalence of vitamin D deficiency across the spectrum of glucose intolerance. J Diabetes Metab Disord 2015;14-54
  • 13 Hari KVS Kumar, Kumar S. Amenorrhea, ptosis and high insulin requirement in a young girl. Diabetes Metab Syndr 2016; 10 (1, suppl 1) S151-S153
  • 14 Hari KVS Kumar, Gupta AK, Kumar A. Clinical profile of patients using normal, high and very high insulin doses in type 2 diabetes. Diabetes Metab Syndr 2014; 8 (02) 72-74
  • 15 Hari Kumar KVS, Modi KD, Jha R. Glycemic control in patients of chronic kidney disease. Int J Diabetes Dev Ctries 2007; 27: 99-103
  • 16 Hari Kumar KVS, Modi KD. A1c, blood pressure and cholesterol goal achievement in patients of type 2 diabetes. Med J DY Patil Univ 2016; 9: 195-199
  • 17 Hari Kumar KVS, Ugale S, Gupta N. et al Ileal interposition with sleeve gastrectomy for control of type 2 diabetes. Diabetes Technol Ther 2009; 11 (12) 785-789
  • 18 Kumar Kota S, Ugale S, Gupta N. et al Remission of type 2 diabetes mellitus by ileal interposition with sleeve gastrectomy. Int J Endocrinol Metab 2011; 9 (03) 374-381
  • 19 Kota SK, Ugale S, Gupta N. Naik V, Hari Kumar KVS, Modi KD. Ileal interposition with sleeve gastrectomy for treatment of type 2 diabetes mellitus. Indian J Endocrinol Metab 2012; 16 (04) 589-598
  • 20 Ugale S, Gupta N, Modi KD. et al Prediction of remission after metabolic surgery using a novel scoring system in type 2 diabetes - a retrospective cohort study. J Diabetes Metab Disord 2014; 13 (01) 89
  • 21 Hari KVS Kumar, Shaikh A, Prusty P. Addition of exenatide or sitagliptin to insulin in new onset type 1 diabetes: a randomized, open label study. Diabetes Res Clin Pract 2013; 100 (02) e55-e58
  • 22 Verma V, Kotwal N, Upreti V. et al Liraglutide as an alternative to insulin for glycemic control in intensive care unit: a randomized, open-label, clinical study. Indian J Crit Care Med 2017; 21 (09) 568-572
  • 23 Hari KVS Kumar, Gupta AK. Clinical audit of patients using DPP4 inhibitors in longstanding type 2 diabetes. Diabetes Metab Syndr 2015; 9 (04) 277-279
  • 24 Hari Kumar KVS, Bhasker S, Banga PK. Pseudoainhum of toes in type 2 diabetes. Int J Diabetes Dev Ctries 2011; 31: 241-242
  • 25 Dhull P, Upreti V, Hari Kumar KVS, Patnaik SK. Hemichorea – hemiballismus in nonketotic hyperglycemia. J Acad Med Sci 2012; 2: 82-84
  • 26 Hari KVS Kumar, Kota SK, Basile A, Modi KD. Profile of microvascular disease in type 2 diabetes in a tertiary health care hospital in India. Ann Med Health Sci Res 2012; 2 (02) 103-108
  • 27 Nachankar A, Kotwal N, Upreti V. Verma V, Hari Kumar KVS. Association of vitamin D and parathyroid hormone with insulin sensitivity, beta cell function and gestational diabetes in pregnancy: a cross-sectional, observational study. Diabetes Ther 2018; 9 (05) 2081-2090
  • 28 Hari KVS Kumar, Ahmad FMH, Sood S, Mansingh S. Visual evoked potential to assess retinopathy in gestational diabetes mellitus. Can J Diabetes 2016; 40 (02) 131-134
  • 29 Hari KVS Kumar, Banga PK, Bansal R, Kalia R. Recurrent insulin injection abscesses: atypical etiology. Indian J Endocrinol Metab 2012; 16 (Suppl. 01) S123-S124
  • 30 Hari KVS Kumar, Pandey I, Singh K, Mukherjee D. Unusual presentation of renal tuberculosis in type 2 diabetes. Niger J Clin Pract 2012; 15 (04) 498-499
  • 31 Hari Kumar KVS, Prajapati J, Pavan G, Parthasarathy A, Jha R, Modi KD. Acquired perforating dermatoses in patients with diabetic kidney disease on hemodialysis. Hemodial Int 2010; 14 (01) 73-77
  • 32 Hari KVS Kumar, Modi KD. Analysis of risk factors for uric acid nephrolithiasis in type 2 diabetes. Saudi J Kidney Dis Transpl 2011; 22 (03) 482-487
  • 33 Dhull P, Tewari AK, Upreti V, Prakash MS, Hari KVS Kumar. Botulinum toxin for meralgia paresthetica in type 2 diabetes. Diabetes Metab Syndr 2013; 7 (01) 1-2
  • 34 Modi KD, Chandwani R, Hari Kumar KVS, Ahmed I, Senthil T. Use of telemedicine in remote screening for retinopathy in type 2 diabetes. Apollo Medicine 2015; 12: 260-263
  • 35 Modi KD, Chandwani R, Ahmed I, Hari Kumar KVS. Discordance between lipid markers used for predicting cardiovascular risk in patients with type 2 diabetes. Diabetes Metab Syndr 2016; 10 (01) (suppl 1) S99-S102
  • 36 Hari Kumar KVS. Sitagliptin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2015; 373 (25) 2478