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CC BY-NC-ND 4.0 · Journal of Coloproctology 2021; 41(03): 222-227
DOI: 10.1055/s-0041-1730425
Original Article

Prevalence of Anal Intraepithelial Lesions in Patients with Inflammatory Bowel Disease

Mariane Christina Savio 
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Rosimeri Kuhl Svoboda Baldin
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Norton Luiz Nóbrega
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Guilherme Mattioli Nicollelli
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Antonio Sérgio Brenner
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Pollyanna Borges da Rocha
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Marssoni Deconto Rossoni
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Maria Cristina Sartor
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
,
Antonio Baldin Junior
1   Coloproctology Service, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil
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Abstract

Introduction Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal canal associated with HPV, with a higher prevalence in immunosuppressed individuals. Patients with inflammatory bowel disease (IBD) are at potential risk for their development, due to the use of immunosuppressants and certain characteristics of the disease.

Method This is a prospective, cross-sectional, and interventional study that included 53 patients with IBD treated at a tertiary outpatient clinic, who underwent anal smear for cytology in order to assess the prevalence of AIN and associated risk factors.

Results Forty-eight samples were negative for dysplasia and 2 were positive (4%). Both positive samples occurred in women, with Crohn's disease (CD), who were immunosuppressed and had a history of receptive anal intercourse.

Discussion The prevalence of anal dysplasia in IBD patients in this study is similar to that described in low-risk populations. Literature data are scarce and conflicting and there is no evidence to recommend screening with routine anal cytology in patients with IBD. Female gender, history of receptive anal intercourse, immunosuppression and CD seem to be risk factors.

Keywords

inflammatory bowel disease (IBD) - anal cancer - anal intraepithelial neoplasia - human papillomavirus (HPV) - Crohn's disease - ulcerative colitis


Publication History

Received: 31 August 2020

Accepted: 15 January 2021

Article published online:
20 September 2021

© 2021. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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