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DOI: 10.1055/s-0041-1730130
Diffuse Leptomeningeal Glioneuronal Tumor in an Adult: A Diagnostic Challenge
Authors
Abstract
Here we report a rare case of diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 35-year-old man, who was misdiagnosed twice as having tuberculosis meningitis and later racemose neurocysticercosis. His delayed diagnosis of DLGNT might be due to prevalence of tuberculosis in our country, similarity in magnetic resonance imaging finding of prominent leptomeningeal enhancement in different cisterns of brain, and extreme rarity of DLGNT in the adults. So, it should be differentiated clinically and radiographically from granulomatous or infectious conditions. Hence, a timely histologic diagnosis through a leptomeningeal biopsy of the brain and spinal cord in case of unusual leptomeningeal enhancement with uncertain laboratory findings is essential because cytological examination of the cerebrospinal fluid in DLGNT is known to be negative.
Publikationsverlauf
Artikel online veröffentlicht:
13. Januar 2022
© 2022. Neurological Surgeons’ Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Rodriguez FJ, Perry A, Rosenblum MK. et al. Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 2012; 124 (05) 627-641
- 2 Louis DN, Perry A, Reifenberger G. et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016; 131 (06) 803-820
- 3 Wesseling P, Capper D. WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol 2018; 44 (02) 139-150
- 4 Kessler BA, Bookhout C, Jaikumar S, Hipps J, Lee YZ. Disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural disease: case report. Clin Imaging 2015; 39 (02) 300-304
- 5 Beck DJ, Russell DS. Oligodendrogliomatosis of the cerebrospinal fluid pathway. Brain 1942; 65: 352-372
- 6 Gardiman MP, Fassan M, Orvieto E. et al. Diffuse leptomeningeal glioneuronal tumors: a new entity?. Brain Pathol 2010; 20 (02) 361-366
- 7 Preuss M, Christiansen H, Merkenschlager A. et al. Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. J Neurooncol 2015; 124 (01) 65-74
- 8 Perry A, Scheithauer BW, Macaulay RJB, Raffel C, Roth KA, Kros JM. Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications. J Neuropathol Exp Neurol 2002; 61 (11) 947-955
- 9 Armao DM, Stone J, Castillo M, Mitchell KM, Bouldin TW, Suzuki K. Diffuse leptomeningeal oligodendrogliomatosis: radiologic/pathologic correlation. AJNR Am J Neuroradiol 2000; 21 (06) 1122-1126
- 10 Ginat DT, Dhillon G, Almast J. Magnetic resonance imaging of neurosarcoidosis. J Clin Imaging Sci 2011; 1: 15
- 11 Dodgshun AJ, SantaCruz N, Hwang J. et al. Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation. J Neurooncol 2016; 128 (02) 293-302