CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2023; 12(01): 022-029
DOI: 10.1055/s-0041-1729782
Original Article

Epidemiology and Clinicopathologic Study of Nonneoplastic Cystic Lesions of the Central Nervous System at a Tertiary Care Center

Mukesh Kumar
1   Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India
2   Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India
Nikita Choudhary
2   Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India
Ashok Singh
2   Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India
Kusum Mathur
2   Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India
› Author Affiliations
Funding None.


Background Nonneoplastic cysts of brain are a diverse group of benign lesions with variable etiopathogenesis. Due to different site and histogenesis, these lesions have wide clinicopathologic spectrum.

Objective The study was performed to evaluate epidemiology and clinicopathologic spectrum of nonneoplastic central nervous system (CNS) cysts highlighting the role of histopathology in the diagnosis as well as to compare the data with other institution's data available in literature.

Materials and Methods All nonneoplastic CNS cysts reported from January 2013 to June 2020 in the Department of Pathology of Sawai Man Singh Medical College, Jaipur, were retrieved and reviewed. The data were evaluated for age, site, cyst wall lining, nature of cyst contents, and location (intracranial and spinal), using SPSS software version 20.0.

Results A total of 255 cases were reviewed with an incidence of 4.96% and an age range of 2 to 74 years with slight male preponderance. Among them there were 157, 34, 26, 24, and 2 cases of epidermoid, arachnoid, dermoid, colloid, and glioependymal cysts, respectively, and 1 case of perineural cyst. Infective cysts were much less common than noninfective cysts, accounting for two cases of neurocysticercosis and hydatid cysts each. All cyst types mainly presented with signs and symptoms of a mass lesion.

Conclusion Nonneoplastic cyst mainly presented like a CNS mass lesion with overlapping clinical features, and image finding revealing the key role of histopathological analysis. Epidermoids were the most common type of these cysts in the present series followed by the arachnoid cysts.

Ethical Approval

Not required, as this was a retrospective analysis of brain tumors that involved the archival tumor blocks and clinicopathological data and did not involve any patient's personal information or any implication on the management protocol. Hence, according to the principles of the Helsinki Declaration, no ethical approval required.

Publication History

Article published online:
13 January 2022

© 2022. Neurological Surgeons' Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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