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DOI: 10.1055/s-0041-1729782
Epidemiology and Clinicopathologic Study of Nonneoplastic Cystic Lesions of the Central Nervous System at a Tertiary Care Center
Authors
Funding None.
Abstract
Background Nonneoplastic cysts of brain are a diverse group of benign lesions with variable etiopathogenesis. Due to different site and histogenesis, these lesions have wide clinicopathologic spectrum.
Objective The study was performed to evaluate epidemiology and clinicopathologic spectrum of nonneoplastic central nervous system (CNS) cysts highlighting the role of histopathology in the diagnosis as well as to compare the data with other institution's data available in literature.
Materials and Methods All nonneoplastic CNS cysts reported from January 2013 to June 2020 in the Department of Pathology of Sawai Man Singh Medical College, Jaipur, were retrieved and reviewed. The data were evaluated for age, site, cyst wall lining, nature of cyst contents, and location (intracranial and spinal), using SPSS software version 20.0.
Results A total of 255 cases were reviewed with an incidence of 4.96% and an age range of 2 to 74 years with slight male preponderance. Among them there were 157, 34, 26, 24, and 2 cases of epidermoid, arachnoid, dermoid, colloid, and glioependymal cysts, respectively, and 1 case of perineural cyst. Infective cysts were much less common than noninfective cysts, accounting for two cases of neurocysticercosis and hydatid cysts each. All cyst types mainly presented with signs and symptoms of a mass lesion.
Conclusion Nonneoplastic cyst mainly presented like a CNS mass lesion with overlapping clinical features, and image finding revealing the key role of histopathological analysis. Epidermoids were the most common type of these cysts in the present series followed by the arachnoid cysts.
Ethical Approval
Not required, as this was a retrospective analysis of brain tumors that involved the archival tumor blocks and clinicopathological data and did not involve any patient's personal information or any implication on the management protocol. Hence, according to the principles of the Helsinki Declaration, no ethical approval required.
Publikationsverlauf
Artikel online veröffentlicht:
13. Januar 2022
© 2022. Neurological Surgeons' Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 HarperCollins. Collins English Dictionary – Complete and Unabridged. 12th ed.. New York: HarperCollins; 2014
- 2 Naveen Kumar S, Vidyadhara Rani P. MRI evaluation of intracranial cystic lesions. Int J Med Res Prof 2017; 3: 151-163
- 3 Din NU, Arshad H, Ahmad Z, Hasan S, Bari ME. Symptomatic surgically treated non-neoplastic cysts of the central nervous system: a clinicopathological study from Pakistan. J Coll Physicians Surg Pak 2015; 25 (08) 588-591
- 4 Russel DS, Rubinstein LJ. Pathology of Tumours of the Nervous System. 5th edition.. Baltimore, MD: Williams & Wilkins; 1989: 693-695
- 5 Ravindran K, Rogers TW, Yuen T, Gaillard F. Intracranial white epidermoid cyst with dystrophic calcification - a case report and literature review. J Clin Neurosci 2017; 42: 43-47
- 6 Bhatt AS, Mhatre R, Nadeesh BN, Mahadevan A, Yasha TC, Santosh V. Nonneoplastic cystic lesions of the central nervous system-histomorphological spectrum: a study of 538 cases. J Neurosci Rural Pract 2019; 10 (03) 494-501
- 7 Sidhu M, Suri VS, Singh D, Tatke M, Kumar S. Histological analysis of cystic tumour like lesions of central nervous system. Indian J Pathol Microbiol 2002; 45 (01) 7-14
- 8 Sundaram C, Paul TR, Raju BV. et al. Cysts of the central nervous system: a clinicopathologic study of 145 cases. Neurol India 2001; 49 (03) 237-242
- 9 Obana WG, Wilson CB. Epidermoid cysts of the brain stem. Report of three cases. J Neurosurg 1991; 74 (01) 123-128
- 10 Iihara K, Kikuchi H, Ishikawa M, Nagasawa S. Epidermoid cyst traversing the pons into the fourth ventricle. Case report. Surg Neurol 1989; 32 (05) 377-381
- 11 Rangacharry SS, Wattanbe J. Ultrastructure and pathogenesis of intracranial arachnoid cysts. J Neuropathol Exp Neurol 1981; 40 (01) 61-83
- 12 Honda E, Fujisawa H, Koyama T, Oshima Y, Sugita Y, Abe T. Symptomatic spinal arachnoid cyst triggered by seat belt injury–case report. Neurol Med Chir (Tokyo) 1998; 38 (03) 168-172
- 13 Ariai S, Koerbel A, Bornemann A, Morgala M, Tatagiba M. Cerebellopontine angle arachnoid cyst harbouring ectopic neuroglia. Pediatr Neurosurg 2005; 41 (04) 220-223
- 14 Gelabert-González M. [Intracranial arachnoid cysts]. Rev Neurol 2004; 39 (12) 1161-1166 (in Spanish)
- 15 Al-Holou WN, Terman S, Kilburg C, Garton HJ, Muraszko KM, Maher CO. Prevalence and natural history of arachnoid cysts in adults. J Neurosurg 2013; 118 (02) 222-231
- 16 Roux A, Mercier C, Larbrisseau A. Dube LJ, Dupuis C, Del Carpio R. Intramedullary epidermoid cysts of the spinal cord. Case report. J Neurosurg 1992; 76 (03) 528-533
- 17 Mc Lendon RE. Epidermoid and dermoid tumours: pathology. In: Wilkins RM, Rengachary SS. eds. Neurosurgery. 2nd edition.. New York: McGraw-Hill; 1996. 1. 959-964
- 18 List CF. Intraspinal epidermoid, dermoid and dermal sinuses. Surg Gynecol Obstet 1941; 73: 525-538
- 19 Maeder PP, Holtås SL, Basibüyük LN, Salford LG, Tapper UA, Brun A. Colloid cysts of the third ventricle: correlation of MR and CT findings with histology and chemical analysis. AJNR Am J Neuroradiol 1990; 11 (03) 575-581
- 20 Lach B, Scheithauer BW, Gregor A, Wick MR. Colloid cyst of the third ventricle. A comparative immunohistochemical study of neuraxis cysts and choroid plexus epithelium. J Neurosurg 1993; 78 (01) 101-111
- 21 Tsuchida T, Hruban RH, Carson BS, Phillips PC. Colloid cysts of the third ventricle: immunohistochemical evidence for nonneuroepithelial differentiation. Hum Pathol 1992; 23 (07) 811-816
- 22 Friede RL, Yasargil MG. Supratentorial ependymal (epithelial) cyst: review, case reports and fine structures. J Neurol Neurosurg Psychiatry 1997; 40 (02) 127-137
- 23 Tarlov IM. Spinal perineurial and meningeal cysts. J Neurol Neurosurg Psychiatry 1970; 33 (06) 833-843
- 24 Osborn AG, Preece MT. Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology 2006; 239 (03) 650-664
- 25 Bladowska J, Bednarek-Tupikowska G, Biel A, Sąsiadek M. Colloid cyst of the pituitary gland: case report and literature review. Pol J Radiol 2010; 75 (02) 88-93
- 26 Park CH, Hyun SJ, Kim KJ, Kim HJ. Spinal intramedullary ependymal cysts: a case report and review of the literature. J Korean Neurosurg Soc 2012; 52 (01) 67-70
- 27 Morishita T, Watanabe T, Ohta T, Fukushima M, Katayama Y. Atypical epidermoid cyst with repetitive hemorrhages in the supracallosal region: case report. Neurol Med Chir (Tokyo) 2009; 49 (10) 492-494
- 28 Chen CY, Wong JS, Hsieh SC, Chu JS, Chan WP. Intracranial epidermoid cyst with hemorrhage: MR imaging findings. AJNR Am J Neuroradiol 2006; 27 (02) 427-429
- 29 Estañol B, Corona T, Abad P. A prognostic classification of cerebral cysticercosis: therapeutic implications. J Neurol Neurosurg Psychiatry 1986; 49 (10) 1131-1134
- 30 Dametto E. Histopathology of the human brain in neurocysticercosis. J Mol Histol Med Physiol 2016; 1: 106
- 31 Dharker SR, Dharker RS, Vaishya ND, Sharma ML, Chaurasia BD. Cerebral hydatid cysts in central India. Surg Neurol 1977; 8 (01) 31-34
- 32 Balasubramaniam V, Ramanujam PB, Ramamurthi B. Hydatid disease of the nervous system. Neurol India 1970; 18 (01) 92-95