CC BY 4.0 · TH Open 2021; 05(02): e188-e194
DOI: 10.1055/s-0041-1729754
Original Article

Management of Cancer-Associated Venous Thrombosis: A Nationwide Survey among Danish Oncologists

1  Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
2  Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
,
Thure Filskov Overvad
2  Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
3  Department of Oncology, Aalborg University Hospital, Aalborg, Denmark
,
Mads Nybo
4  Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
,
Thomas Kümler
5  Department of Cardiology, Herlev- Gentofte Hospital, Copenhagen, Denmark
,
Morten Schnack Rasmussen
6  Department of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Denmark
,
Thomas Decker Christensen
7  Department of Cardiothoracic and Vascular Surgery and Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
,
Torben Bjerregaard Larsen
1  Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
2  Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
› Author Affiliations
Funding T.D.C. reports personal fees from AstraZeneca, Boehringer-Ingelheim, Roche Diagnostics, Merck Sharp & Dohme (MSD), and Bristol Myers Squibb outside the submitted work. A.A.H. reports personal fees from Merck Sharp & Dohme, Bayer, and The Bristol-Myers Squibb-Pfizer Alliance outside the submitted work.

Abstract

Background Treatment patterns for cancer-associated venous thrombosis (CAT) has been shown to be nonconsistent with contemporary guideline recommendations, resulting in poor patient outcomes.

Objectives The study aimed to describe contemporary CAT management in Danish oncology departments and identify knowledge gaps and inconsistencies between guidelines and clinical practice.

Patients and Methods A survey questionnaire in Danish was developed based on contemporary national guidelines. Using an open recruitment strategy, invitations to participate in the electronic survey were sent to physicians employed at oncology departments in Denmark in winter of 2018/2019. The questionnaire was based on current national guidelines and included 10 items with multiple choices and a free-text option to specify or comment. The questionnaire was pilot-tested by a junior and senior oncologist.

Results A total of 142 physicians completed the survey, representing all Danish geographical regions and various seniority. The majority reported that CAT was treated and followed up in oncology departments. However, 36.6% of the physicians were unaware of the existence of designated cancer thrombosis guidelines. Risk of venous thrombosis was generally assessed without diagnostic scores. Almost all (98.6%) reported low-molecular-weight heparin to be first-line treatment for CAT. Treatment duration seemed wrongly influenced by subtype of venous thrombosis, and 44.5% responded that thromboprophylaxis among hospitalized patients was substantially underused.

Conclusion The variability in the daily clinical management of CAT demonstrated through this survey indicates a potential to increase awareness of available guidelines, standardized use of inpatient thromboprophylaxis, and organized treatment and follow-up in a multidisciplinary setting, which would potentially improve management of CAT in Denmark.

Authors' Contributions

A.A.H. drafted the survey questionnaire, chaired the project, analyzed the survey results, and drafted the manuscript. T.F.O., M.N., T.K., M.S.R., T.D.C., and T.B.L. revised the survey questionnaire, revised the manuscript, and approved the final version to be published.


Supplementary Material



Publication History

Received: 01 December 2020

Accepted: 19 January 2021

Publication Date:
16 June 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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