CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2021; 42(01): 077-079
DOI: 10.1055/s-0041-1729434
Trainees’ Corner

Liquid Biopsy

Amit Kumar Jain
1   Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India
Guruprasad Bhat
2   Department of Medical Oncology, Yenepoya Specialty Hospital, Mangalore, Karnataka, India
Vineet Govinda Gupta
1   Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India
Hari Goyal
1   Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India
› Author Affiliations

In the note below, we shall be discussing in brief about liquid biopsy in cancer under the following headings.

  • Definition

  • Need/advantages of liquid biopsy

  • Types

  • Methodology

  • Limitations

  • Uses in oncology

  • Approved

  • In research

  • Future implication

  • References

Publication History

Article published online:
20 May 2021

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  • References

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  • 2 Diaz Jr LA, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol 2014; 32 (06) 579-586
  • 3 Rolfo C, Castiglia M, Hong D. et al. Liquid biopsies in lung cancer: the new ambrosia of researchers. Biochim Biophys Acta 2014; 1846 (02) 539-546
  • 4 Paterlini-Bréchot P. Circulating tumor cells: who is the killer?. Cancer Microenviron 2014; 7 (03) 161-176
  • 5 Klevebring D, Neiman M, Sundling S. et al. Evaluation of exome sequencing to estimate tumor burden in plasma. PLoS One 2014; 9 (08) e104417
  • 6 Joosse SA, Pantel K. Tumor-educated platelets as liquid biopsy in cancer patients. Cancer Cell 2015; 28 (05) 552-554
  • 7 Murray NP, Miranda R, Ruiz A, Droguett E. Diagnostic yield of primary circulating tumor cells in women suspected of breast cancer: the BEST (Breast Early Screening Test) study. Asian Pac J Cancer Prev 2015; 16 (05) 1929-1934
  • 8 Lv Q, Gong L, Zhang T. et al. Prognostic value of circulating tumor cells in metastatic breast cancer: a systemic review and meta-analysis. Clin Transl Oncol 2016; 18 (03) 322-330