CC BY-NC-ND 4.0 · Indian Journal of Medical and Paediatric Oncology 2021; 42(01): 110-112
DOI: 10.1055/s-0041-1729342
Case Report with Review of Literature

Excellent Radiological Response with Modern Contemporary Proton Beam Therapy in Favorable Molecular Low-Intermediate Grade Oligodendroglioma: A Report of Two Cases

Raees Tonse
1  Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
MP Noufal
2  Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Dayananda Shamurailatpam
2  Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Rakesh Jalali
1  Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
› Author Affiliations

Abstract

Radiotherapy (RT) has been a long-standing treatment option for low-grade glioma. Improvements in tumor control and reduced radiation-related toxicity can be attributed to advances in neuroimaging as well as RT treatment planning and delivery techniques. The molecular markers such as isocitrate dehydrogenase and lpl9q play a key role in determining which patients will benefit most from combined radiation and systemic therapy. We hereby report two cases of favorable molecular low-intermediate grade oligodendroglioma treated with modern proton pencil-beam therapy under high-precision image guidance showing excellent radiological response that is usually not seen with conventional photon radiation.



Publication History

Publication Date:
28 May 2021 (online)

© 2021. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India