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Histone-DNA Complexes and Coagulation after Intracerebral and Subarachnoid HemorrhageFunding This study received its financial support from Aarhus University, Aarhus, Denmark (project no. 18829), Oda and Hans Svenningsen's Foundation (grant no. BOF-10109), Helga and Peter Korning's Foundation (grant no. 55027-60) and Health Research Foundation of Central Denmark Region. The funding sources did not influence study design, data collection or analysis.
Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) have limited treatment options and a high mortality. We have previously shown that both conditions are associated with early hypercoagulation. 
Histones have been demonstrated to promote thrombin generation. In sepsis and trauma patients, studies have revealed an association between histone-DNA complexes and free histone levels and mortality or morbidity.   Theoretically, the effects on coagulation of histones can be investigated in vitro by attempting to block histones with specific antibodies.
The aim of this study was to quantify histone-DNA complex levels in patients with ICH or SAH at the time of admission to hospital compared with 24 hours after symptom onset and to investigate the possible in vitro effect of anti-histone antibodies on thrombin generation.
Received: 15 November 2020
Accepted: 26 January 2021
14 April 2021 (online)
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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