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CC BY 4.0 · TH Open 2021; 05(02): e171-e173
DOI: 10.1055/s-0041-1728664
Case Report

Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Kiyoko Kanosue
1   Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan
,
Satomi Nagaya
2   Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
,
Eriko Morishita
2   Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
,
Masayoshi Yamanishi
1   Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan
,
Shinsaku Imashuku 
3   Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan
› Author Affiliations Funding None.
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Abstract

A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation.

Keywords

visceral vein thrombosis - protein C deficiency - Clostridium perfringens - septicemia - older adult

Policy and Ethics

The work was performed in accordance with the Declaration of Helsinki with approval by the Institutional Ethics Committee.


Supplementary Material



Publication History

Received: 20 January 2021

Accepted: 23 February 2021

Article published online:
26 May 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Dinarvand P, Moser KA. Protein C deficiency. Arch Pathol Lab Med 2019; 143 (10) 1281-1285
    CrossrefPubMedGoogle Scholar
  • 2 Makoto I, Usui M, Wada H. et al. Congenital thrombophilia in patients with superior mesenteric venous thrombosis or portal vein thrombosis. Clin Appl Thromb Hemost 2018; 24 (07) 1117-1121
    CrossrefPubMedGoogle Scholar
  • 3 Millar DS, Johansen B, Berntorp E. et al. Molecular genetic analysis of severe protein C deficiency. Hum Genet 2000; 106 (06) 646-653
    PubMedGoogle Scholar
  • 4 Faccia M, Ainora ME, Ponziani FR. et al. Portal vein thrombosis in cirrhosis: why a well-known complication is still matter of debate. World J Gastroenterol 2019; 25 (31) 4437-4451
    CrossrefPubMedGoogle Scholar
  • 5 Rodríguez-Leal GA, Morán S, Corona-Cedillo R, Brom-Valladares R. Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient. World J Hepatol 2014; 6 (07) 532-537
    CrossrefPubMedGoogle Scholar
  • 6 Schweigart JH, Klotsas A, Schelenz S, Dhatariya K. Portal vein thrombosis despite anticoagulation in a person with diabetes. J R Soc Med 2005; 98 (04) 161-163
    CrossrefPubMedGoogle Scholar
  • 7 Shin DH, Park JH, Yoon KW, Shin JH, Kim SJ. Clostridium perfringens septicemia with thrombophlebitis of the portal vein. J Infect 2003; 46 (04) 253-255
    CrossrefPubMedGoogle Scholar
  • 8 Reitsma PH, Bernardi F, Doig RG. et al. Protein C deficiency: a database of mutations, 1995 update. On behalf of the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH. Thromb Haemost 1995; 73 (05) 876-889
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Miyata T, Kato H, Sakata T. et al. Congenital thrombophilia caused by protein C deficiency [in Japanese]. Rinsho Byori 2000; 48 (04) 285-292
    PubMedGoogle Scholar
  • 10 Inoue H, Terachi SI, Uchiumi T. et al. The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene. Pediatr Blood Cancer 2017; 64 (07) e26404
    CrossrefPubMedGoogle Scholar
  • 11 Miyata T, Sakata T, Yasumuro Y. et al. Genetic analysis of protein C deficiency in nineteen Japanese families: five recurrent defects can explain half of the deficiencies. Thromb Res 1998; 92 (04) 181-187
    CrossrefPubMedGoogle Scholar
  • 12 Ueda K, Morishita E, Shiraki H, Matsuoka S, Imashuku S. Aortic mural thrombus associated with congenital protein C deficiency in an elderly patient. J Atheroscler Thromb 2020; 27 (01) 100-103
    CrossrefPubMedGoogle Scholar